Cel The project is aimed at a comprehensive analysis of the pathophysiology of a group of rare, but severe and chronic autoimmune bullous skin disorders, the pemphigoids (PEs), characterized by defective epithelial adhesion and autoantibodies against components of the skin basement membrane zone. These diseases represent a prototype of organ-specific autoimmune disorders which share common pathogenetic mechanisms. The objectives are: the analysis of molecular interactions and processing of epithelial adhesion proteins targets in the PEs; the characterization of the humoral immune responses and T cell immune responses in the PEs; the study of disease development risk factors. Expected results are: (i) a better understanding of the immunopathogenesis of PEs disorders; (ii) the definition of markers for disease severity, progression and outcome, (iii) the identification of subjects at risk for disease, (iv) the development of new diagnostic tools and of (v) novel immunotherapy for these diseases. Altogether these results will also enhance understanding and allow development of new diagnostic and therapeutic approaches in other autoimmune disorders. Dziedzina nauki medical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologyimmunotherapy Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELL'IMMACOLATA CONCEZIONE - ISTITUTO DERMOPATICO DELL'IMMACOLATA Wkład UE Brak danych Adres Via dei Monti di Creta 104 00167 ROMA Włochy Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francja Wkład UE Brak danych Adres Avenue de Valombrose 28 06107 NICE Zobacz na mapie Koszt całkowity Brak danych UNIVERSITAETSKLINIKUM FREIBURG Niemcy Wkład UE Brak danych Adres Hauptstrasse 7 79104 FREIBURG (IN BREISGAU) Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF ERLANGEN-NUREMBERG Niemcy Wkład UE Brak danych Adres 14,Hartmannstrasse 14 91052 Erlangen Zobacz na mapie Koszt całkowity Brak danych WIESLAB AB Szwecja Wkład UE Brak danych Adres Ideon Research Park 223 70 LUND Zobacz na mapie Koszt całkowity Brak danych
