Objective To unravel the molecular mechanisms underlying proper mammalian development is one of the most pressing tasks for modern biomedical science. The complicated processes leading to genetic disease can only be understood, if we comprehend normal development. To study differentiation processes we have decided to focus on the development of the go- and, which is widely believed to be the best model system. We are planning to elucidate differentiation on a molecular level using a variety of approaches. In vitro studies will be performed to define interactions between known factors. Transgenic and knock-out animals will be generated to analyse gene function in an in vivo environment. Positional cloning of genes from patients with sex-reversal phenotypes will be used to identify new players in the explore patterns of evaluation in this highly diverged system. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-8. - Research into genomes and diseases of genetic origin Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF NEWCASTLE UPON TYNE EU contribution No data Address Central Parkway NE1 3BZ NEWCASTLE UPON TYNE United Kingdom See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue de la Cardonille 141 34396 MONTPELLIER See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Crewe Road Western General Hospital EH4 2XU EDINBURGH See on map Total cost No data UNIVERSITA DEGLI STUDI DI PAVIA Italy EU contribution No data Address Via Forlanini 14 27100 PAVIA See on map Total cost No data