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Content archived on 2024-05-27

Novel mechanisms of cell communication in the nervous system : physiology and function of the p75 neurotrophin receptor

Objective

The goal of this project is to elucidate novel signalling pathways for cell communication in the nervous system using the paradigm of the p75 neurotrophin receptor (p75NTR). This receptor is at the cross-roads of biological processes important for the development, maintenance and function of the nervous system, including neuron survival/death decisions, axonal growth, responses to lesions and environmental stimuli, and neurotropic viral infection. Our strategy is to increase the knowledge base on the physiology and signalling capabilities of neuronal communication of general applicability. To this end, we propose studies o intracellular mechanisms of p75NTR signalling, cooperation with Trk receptors, structure-function relationships, novel second messenger molecules, target genes regulated by p75NTR, neurophysiological roles, and p75NTR gene promoter regulation.

Call for proposal

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Coordinator

KAROLINSKA INSTITUTE
EU contribution
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Address
Retzius vaeg 8
171 77 STOCKHOLM
Sweden

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Total cost
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Participants (8)