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Novel mechanisms of cell communication in the nervous system : physiology and function of the p75 neurotrophin receptor

Objective

The goal of this project is to elucidate novel signalling pathways for cell communication in the nervous system using the paradigm of the p75 neurotrophin receptor (p75NTR). This receptor is at the cross-roads of biological processes important for the development, maintenance and function of the nervous system, including neuron survival/death decisions, axonal growth, responses to lesions and environmental stimuli, and neurotropic viral infection. Our strategy is to increase the knowledge base on the physiology and signalling capabilities of neuronal communication of general applicability. To this end, we propose studies o intracellular mechanisms of p75NTR signalling, cooperation with Trk receptors, structure-function relationships, novel second messenger molecules, target genes regulated by p75NTR, neurophysiological roles, and p75NTR gene promoter regulation.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
Retzius Vaeg 8
171 77 Stockholm
Sweden

Participants (8)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Cnrs, Avenue De La Terrace, Bat. 14
91198 Gif Sur Yvette
ESTONIAN INSTITUTE OF EXPERIMENTAL AND CLINICAL MEDICINE
Estonia
Address
Hiiu 42
0016 Tallinn
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Avenue De La Terrasse
91198 Gif Sur Yvette
UNIVERSITE DE PARIS-SUD XI
France
Address
Rue Georges Clemenceau 15
91405 Gometz La Ville
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
30,Guilford Street 30
WC1N 1EH London
UNIVERSITY OF BOLOGNA
Italy
Address
Via Zamboni 33
40126 Bologna
University of Edinburgh
United Kingdom
Address
Old College South Bridge
EH1 1HN Edinburgh
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzel Street 2
P.O.Box 26 Rehovot