Obiettivo The goal of this project is to elucidate novel signalling pathways for cell communication in the nervous system using the paradigm of the p75 neurotrophin receptor (p75NTR). This receptor is at the cross-roads of biological processes important for the development, maintenance and function of the nervous system, including neuron survival/death decisions, axonal growth, responses to lesions and environmental stimuli, and neurotropic viral infection. Our strategy is to increase the knowledge base on the physiology and signalling capabilities of neuronal communication of general applicability. To this end, we propose studies o intracellular mechanisms of p75NTR signalling, cooperation with Trk receptors, structure-function relationships, novel second messenger molecules, target genes regulated by p75NTR, neurophysiological roles, and p75NTR gene promoter regulation. Campo scientifico natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinephysiology Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-9. - Neurosciences Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore KAROLINSKA INSTITUTE Contributo UE Nessun dato Indirizzo Retzius vaeg 8 171 77 STOCKHOLM Svezia Mostra sulla mappa Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo CNRS, Avenue de la Terrace, Bat. 14 91198 GIF SUR YVETTE Mostra sulla mappa Costo totale Nessun dato ESTONIAN INSTITUTE OF EXPERIMENTAL AND CLINICAL MEDICINE Estonia Contributo UE Nessun dato Indirizzo Hiiu 42 0016 TALLINN Mostra sulla mappa Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo Avenue de la Terrasse 91198 GIF SUR YVETTE Mostra sulla mappa Costo totale Nessun dato UNIVERSITE DE PARIS-SUD XI Francia Contributo UE Nessun dato Indirizzo Rue Georges Clemenceau 15 91405 GOMETZ LA VILLE Mostra sulla mappa Costo totale Nessun dato UNIVERSITY COLLEGE LONDON Regno Unito Contributo UE Nessun dato Indirizzo 30,Guilford Street 30 WC1N 1EH LONDON Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF BOLOGNA Italia Contributo UE Nessun dato Indirizzo Via Zamboni 33 40126 BOLOGNA Mostra sulla mappa Costo totale Nessun dato University of Edinburgh Regno Unito Contributo UE Nessun dato Indirizzo Old College South Bridge EH1 1HN Edinburgh Mostra sulla mappa Costo totale Nessun dato WEIZMANN INSTITUTE OF SCIENCE Israele Contributo UE Nessun dato Indirizzo Herzel Street 2 P.O.Box 26 REHOVOT Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato