Role for the endogenous cannabinoid system in ethanol and nicotine addiction: implications for the treatment of drug abuse (CANNABINOID ALCOHOLISM)

Project Information

CANNABINOID ALCOHOLI

Grant agreement ID: QLG4-CT-2001-01691

Project closed

Start date 1 January 2002

End date 31 December 2004

Funded under

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Total cost € 585 936,00

EU contribution € 459 772,00

Coordinated by

UNIVERSIDAD COMPLUTENSE DE MADRID
Spain

Objective

This proposal is aimed to explore the role of the endogenous cannabinoid system (ECS) on the development of ethanol and nicotine tolerance, rewarding effects and physical dependence. The studies will be done in normal mice and rats as well as in CB1 knockout mice and Sardinian Alcohol Proffering rats. We will characterize the changes induced by acute or chronic ethanol/nicotine administration on the ECS, (Enzymes for synthesis and metabolism of endocannabinoids and cannabinoid CB1 receptors and its transudation systems), as well as the activity of drugs acting at the ECS in drug ethanol/nicotine self administration and withdrawal. The final goal is to investigate the utility of drugs targeting the ECS for the treatment of alcoholism and tobacco addiction.

Fields of science

• medical and health sciences › health sciences › substance abuse
• natural sciences › chemical sciences › organic chemistry › alcohols
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-10. - Public health and health services research

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIDAD COMPLUTENSE DE MADRID

• EU contribution: No data
• Address: Campus de Somosaguas, Edificio Lateral II ; 28223 MADRID ; Spain
• Total cost: No data

Participants (4)

CENTRO CONSORTILE RICERCHE NEUROPSICOFARMACOLOGICHE A.R.L.

Italy

• EU contribution: No data
• Address: Z.I. di Macchiareddu, Sesta Strada Ovest ; 09010 BUGGERRU
• Total cost: No data

UNIVERSITAT POMPEU FABRA

Spain

• EU contribution: No data
• Address: C/ Dr. Aiguader 80 ; 08003 BARCELONA
• Total cost: No data

UNIVERSITE LIBRE DE BRUXELLES

Belgium

• EU contribution: No data
• Address: 808,Route de Lennik 808 Campus Erasme - Building C ; 1070 BRUXELLES
• Total cost: No data

UNIVERSITY OF CAGLIARI

Italy

• EU contribution: No data
• Address: Citadella Universitaria di Monserrato ; 09042 MONSERRATO
• Total cost: No data