Role for the endogenous cannabinoid system in ethanol and nicotine addiction: implications for the treatment of drug abuse (CANNABINOID ALCOHOLISM)

Información del proyecto

CANNABINOID ALCOHOLI

Identificador del acuerdo de subvención: QLG4-CT-2001-01691

Proyecto cerrado

Fecha de inicio 1 Enero 2002

Fecha de finalización 31 Diciembre 2004

Financiado con arreglo a

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Coste total € 585 936,00

Aportación de la UE € 459 772,00

Coordinado por

UNIVERSIDAD COMPLUTENSE DE MADRID
Spain

Objetivo

This proposal is aimed to explore the role of the endogenous cannabinoid system (ECS) on the development of ethanol and nicotine tolerance, rewarding effects and physical dependence. The studies will be done in normal mice and rats as well as in CB1 knockout mice and Sardinian Alcohol Proffering rats. We will characterize the changes induced by acute or chronic ethanol/nicotine administration on the ECS, (Enzymes for synthesis and metabolism of endocannabinoids and cannabinoid CB1 receptors and its transudation systems), as well as the activity of drugs acting at the ECS in drug ethanol/nicotine self administration and withdrawal. The final goal is to investigate the utility of drugs targeting the ECS for the treatment of alcoholism and tobacco addiction.

Ámbito científico

• medical and health sciences › health sciences › substance abuse
• natural sciences › chemical sciences › organic chemistry › alcohols
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programa(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Tema(s)

• 1.1.1.-10. - Public health and health services research

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

UNIVERSIDAD COMPLUTENSE DE MADRID

• Aportación de la UE: Sin datos
• Dirección: Campus de Somosaguas, Edificio Lateral II ; 28223 MADRID ; España
• Coste total: Sin datos

Participantes (4)

CENTRO CONSORTILE RICERCHE NEUROPSICOFARMACOLOGICHE A.R.L.

Italia

• Aportación de la UE: Sin datos
• Dirección: Z.I. di Macchiareddu, Sesta Strada Ovest ; 09010 BUGGERRU
• Coste total: Sin datos

UNIVERSITAT POMPEU FABRA

España

• Aportación de la UE: Sin datos
• Dirección: C/ Dr. Aiguader 80 ; 08003 BARCELONA
• Coste total: Sin datos

UNIVERSITE LIBRE DE BRUXELLES

Bélgica

• Aportación de la UE: Sin datos
• Dirección: 808,Route de Lennik 808 Campus Erasme - Building C ; 1070 BRUXELLES
• Coste total: Sin datos

UNIVERSITY OF CAGLIARI

Italia

• Aportación de la UE: Sin datos
• Dirección: Citadella Universitaria di Monserrato ; 09042 MONSERRATO
• Coste total: Sin datos