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Evaluation of the prevalence of the coeliac disease and its genetic components in the european population

Objective

TECHNOLOGICAL PROBLEM

Coeliac disease is an autoimmune type disease characterised by intolerance to gluten (gluten is a major food ingredient extracted from cereals like wheat, rye and barley). In genetically susceptible individuals, gluten ingestion results in intestinal mucosa damage and malabsorption of essential nutrients.
The coeliac-EU cluster groups together three research programmes with complementary scientific objectives:
To establish the prevalence of oeliac disease in a large European population.
To characterise the genetic basis of this common food intolerance.
To identify factors involved in the gluten-triggered pathogenesis of mucosal damage.


EXPECTED RESULTS

The epidemiology study will :
Provide an estimate of the prevalence of oeliac disease in Europe.
Allow identification and early treatment of 'silent' oeliac people who are so far not detected.

The genetic study will :
Identify association(s) between gene(s) and the oeliac disease.
Clarify the contribution of the HLA genetic components and their association with other (non-HLA) genetic markers.

The pathogenesis study will :
Characterise features of damage in the oeliac mucosa.
Provide information on factors involved in the pathogenesis of mucosal damage, in particular on T cells involvement.


APPLICATIONS

A new simple serological diagnostic test, suitable for large population screening and allowing an easier and earlier detection of the disease, will be validated.
A non-invasive genetic test based on DNA analysis may potentially be developed in the future.
New therapeutic strategies, for instance based on immuno-modulation, may potentially be developed in the future.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

AMYLUM-BELGIUM NV
Address
10,Burchstraat 10
9300 Aalst
Belgium

Participants (14)

EUROSPITAL S.P.A.
Italy
Address
Via Flavia 122
34147 Trieste
FINNISH RED CROSS BLOOD TRANSFUSION SERVICE
Finland
Address
Kivihaantie 7
00310 Helsinki
GOETEBORG UNIVERSITY
Sweden
Address
Vasaparken
405 30 Goeteborg
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Neuherberg
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
WC2R 2LS London
QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
Address

BT7 1NN Belfast
THE MATHILDA AND TERENCE KENNEDY INSTITUTE OF RHEUMATOLOGY
United Kingdom
Address
1,Aspenlea Road 1 Hammersmith
W6 7LH London
UNIVERSITA POLITECNICA DELLE MARCHE
Italy
Address
Via Corridoni 11 Ospedale Salesi
60123 Ancona
UNIVERSITY OF ERLANGEN-NUREMBERG
Germany
Address
Egerlandstrasse 1
91058 Erlangen
UNIVERSITY OF OSLO
Norway
Address
27,Pilestredet 32 Rikshospitalet
0027 Oslo
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Address
Tremoda Road - Southampton General Hospital
SO16 6YD Southampton
UNIVERSITY OF TAMPERE
Finland
Address
Kalevantie 4
33014 Tampere
Università degli Studi di Napoli 'Federico II'
Italy
Address
Corso Umberto I 34
80138 Napoli