Objective
TECHNOLOGICAL PROBLEM
Coeliac disease is an autoimmune type disease characterised by intolerance to gluten (gluten is a major food ingredient extracted from cereals like wheat, rye and barley). In genetically susceptible individuals, gluten ingestion results in intestinal mucosa damage and malabsorption of essential nutrients.
The coeliac-EU cluster groups together three research programmes with complementary scientific objectives:
To establish the prevalence of oeliac disease in a large European population.
To characterise the genetic basis of this common food intolerance.
To identify factors involved in the gluten-triggered pathogenesis of mucosal damage.
EXPECTED RESULTS
The epidemiology study will :
Provide an estimate of the prevalence of oeliac disease in Europe.
Allow identification and early treatment of 'silent' oeliac people who are so far not detected.
The genetic study will :
Identify association(s) between gene(s) and the oeliac disease.
Clarify the contribution of the HLA genetic components and their association with other (non-HLA) genetic markers.
The pathogenesis study will :
Characterise features of damage in the oeliac mucosa.
Provide information on factors involved in the pathogenesis of mucosal damage, in particular on T cells involvement.
APPLICATIONS
A new simple serological diagnostic test, suitable for large population screening and allowing an easier and earlier detection of the disease, will be validated.
A non-invasive genetic test based on DNA analysis may potentially be developed in the future.
New therapeutic strategies, for instance based on immuno-modulation, may potentially be developed in the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences public health epidemiology
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9300 AALST
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.