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Zinc effects on nutrient / nutrient interactions and trends in health and ageing.

Objective

Intake of protective nutritional components, including zinc, is critical for older people. Zinc enrichment may be beneficial for health, but excess zinc may interact with Fe and Cu metabolism. We propose to determine the response to nutritional supplementation of zinc in cohorts of late middle-aged and older men and women from different European countries. Volunteers will receive a placebo or two levels of zinc supplement for 6 months. Effects of zinc supplementation on relevant micronutrient status and intestinal absorption of zinc will be evaluated. Cognitive function and psychological and physiological factors will be monitored. Beneficial effects and possible adverse effects, on surrogate biomarkers of health and physiological factors, will be detonated at baseline, 3 and 6 months of zinc supplementation. This proposal will provide a scientific basis for formulation of public health recommendations on dietary zinc intake in ageing Europeans.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (5)

CAMBRIDGE COGNITION LTD
United Kingdom
Address
Turnbridge Court, Turnbridge Lane, Bottisham
CB5 9DU Cambridge
NATIONAL INSTITUTE OF RESEARCH FOR FOOD AND NUTRITION
Italy
Address
546,Via Ardeatina 546
00178 Roma
UNIVERSITE JOSEPH FOURIER - GRENOBLE 1
France
Address
Avenue Centrale 621
38041 Grenoble
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
Address
Western Road
30 Cork
UNIVERSITY OF ULSTER
United Kingdom
Address
Cromore Road
BT52 1SA Coleraine