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Strategy to control spread of hiv drug resistance (SPREAD)

Objective

Human immunodeficiency viruses resistant to one or more HIV drugs are spreading throughout the world. If further spread of resistant HIV will not be controlled, a future situation may occur, in which no effective HIV drugs will be available for newly infected patients. The size of this problem in Europe is currently unknown, but it is estimated that approximately one fifth of all new infections are due to drug resistant viruses. No systematic information is collected and no strategy is available to prevent further spread of resistant viruses. Within the SPREAD-project clinicians, virologists and epidemiologists from 16 European countries will develop a strategy to control transmission of resistant HIV. They will collect data to reliably determine the incidence of transmission within the different risk groups and to identify risk factors enhancing the risk of transmission. Viruses from 4000 newly diagnosed individuals will be collected between 2001 and 2004 and characterised on mutational and phenotypic level by a network of quality controlled national reference laboratories. The data will be analysed using models and will be used to identify risk groups and predict future trends. Based on these analyses a European strategy will be developed and implemented in collaboration with public health authorities, the clinical community, pharmaceutical industry and patient...

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY HOSPITAL UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands

Participants (17)

CENTRE DE RECHERCHE PUBLIC DE LA SANTE
Luxembourg
Address
Route Barble 4
1210 Luxembourg
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
Spain
Address
Ctra. De Canyet S/n, Hospital Universitari Germans
08916 Badalona
HELLENIC SCIENTIFIC SOCIETY FOR THE STUDY OF AIDS AND SEXUALLY TRANSMITTED DISEASES
Greece
Address
Dragoumi Street 5
16121 Kaisariani / Athens
HOSPITAL DE EGAS MONIZ S.A
Portugal
Address
Rua Da Junqueira 126
1349-019 Lisboa
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Arc Building, Aspenlea Road 1
W6 8LH London
KAROLINSKA INSTITUTE
Sweden
Address
Huddinge University Hospital
141 86 Huddinge
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
10,Minderbroedersstraat 10
3000 Louvain / Leuven
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
Mannerheimintie 16
00300 Helsinki
NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Address
Belfield
4 Dublin
NORWEGIAN INSTITUTE OF PUBLIC HEALTH
Norway
Address
Geitmyrsveien 75, Torshov
0403 Oslo
ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL OF UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Rowland Hill Street
HP16 0JS Great Missenden/prestwood
STATENS SERUM INSTITUT
Denmark
Address
Artillerivej 5
2300 Koepenhagen
THE UNIVERSITY OF MILANO
Italy
Address
L. Sacco Hospital, Via Gb Grassi 74
20157 Milano
UNIVERSITY OF ERLANGEN-NUREMBERG
Germany
Address
4,Schlossgarten 4
91054 Erlangen
UNIVERSITY OF VIENNA
Austria
Address
Kinderspitalgasse 15
1095 Wien
VIROLOGY NETWORKS BV
Netherlands
Address
Maliebaan 24-26
3581 CP Utrecht
WOJEWODZKI SZPITAL ZAKAZNY
Poland
Address
Wolkska 37
01 201 Warszawa