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Polysaccharide molecular engineering. the use of mannuronan c-5 epimerases for the upgrading of alginates and artificial heteromannuronans.

Objective

POLYENG aims at developing a set of highly efficient biomolecules, alginates and other uronic acid containing biopolymers, with a wide variety of programmable properties designed for advanced drug delivery systems or as encapsulation matrix for cells. The technology is based on a unique set of recently discovered polymer modifying C-5 epimerases with capacity to introduce sites for cooperative ion binding into soluble polyuronates. Through enzymatic modification we will control the sequential structure of these polymers and thus tailor their properties essential to their use as gel matrices in pharmaceuticals drug delivery, in bioreactors, and cell therapeutic systems. POLYENG will develop these enzymes from bacteria and algae into robust tools. The epimerisation process will be optimised and the structure and functional properties of the new materials will be evaluated both on molecular bases and in applications.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Address
Alfred Getz Vei 2B
7941 Trondheim
Norway

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Place George Tessier
29682 Roscoff
FMC Biopolymer AS
Norway
Address
Tomtegata 36
Drammen
RECKITT BENCKISER HEALTHCARE (UK) LTD
United Kingdom
Address
Bath Road 103-105
SL1 3UH Slough
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
2,Piazzale Aldo Moro 5
00185 Roma
UPPSALA UNIVERSITY
Sweden
Address
3,Husargatan 3
751 23 Uppsala