Obiettivo
POLYENG aims at developing a set of highly efficient biomolecules, alginates and other uronic acid containing biopolymers, with a wide variety of programmable properties designed for advanced drug delivery systems or as encapsulation matrix for cells. The technology is based on a unique set of recently discovered polymer modifying C-5 epimerases with capacity to introduce sites for cooperative ion binding into soluble polyuronates. Through enzymatic modification we will control the sequential structure of these polymers and thus tailor their properties essential to their use as gel matrices in pharmaceuticals drug delivery, in bioreactors, and cell therapeutic systems. POLYENG will develop these enzymes from bacteria and algae into robust tools. The epimerisation process will be optimised and the structure and functional properties of the new materials will be evaluated both on molecular bases and in applications.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical sciencespolymer sciences
- natural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates
- engineering and technologyother engineering and technologiesmicrotechnologymolecular engineering
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Argomento(i)
Invito a presentare proposte
Data not availableMeccanismo di finanziamento
CSC - Cost-sharing contractsCoordinatore
7941 TRONDHEIM
Norvegia