Objective This proposal is focused on the use of conopeptide scaffolds for discovery and engineering of novel analgesics. A combination of polemic and selection methodologies will be used to identify conopeptide legends for receptors of clinical importance in chronic and naturopathic pain syndromes, namely the SNS tetrodotoxin-resistant sodium channel, and the p75 neurotrophin receptor. The multidisciplinary research program combines efforts of seven academic and two industrial groups, working in fields that include protein chemistry, protein folding and engineering, functional genomic, interaction selection systems, molecular physiology of pain pathways, and CNS delivery mechanisms. Fields of science natural scienceschemical sciencesinorganic chemistryalkali metalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingmedical and health sciencesbasic medicinephysiology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator WEIZMANN INSTITUTE OF SCIENCE EU contribution No data Address Herzel Street, 2 76100 REHOVOT Israel See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address Batiment 152, CEA/SACLAY 91191 GIF SUR YVETTE See on map Total cost No data LUND UNIVERSITY Sweden EU contribution No data Address Wallenberglaboratoriet, ingang 46 205 02 MALMOE See on map Total cost No data TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israel EU contribution No data Address Efron Street 7 31096 HAIFA See on map Total cost No data TEL AVIV UNIVERSITY Israel EU contribution No data Address Ramat Aviv 69987 TEL AVIV See on map Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Gower Street LONDON See on map Links Website Opens in new window Total cost No data
