From conopeptide scaffolds to analgesic leads

Objective

This proposal is focused on the use of conopeptide scaffolds for discovery and engineering of novel analgesics. A combination of polemic and selection methodologies will be used to identify conopeptide legends for receptors of clinical importance in chronic and naturopathic pain syndromes, namely the SNS tetrodotoxin-resistant sodium channel, and the p75 neurotrophin receptor. The multidisciplinary research program combines efforts of seven academic and two industrial groups, working in fields that include protein chemistry, protein folding and engineering, functional genomic, interaction selection systems, molecular physiology of pain pathways, and CNS delivery mechanisms.

Fields of science

• natural sciences › chemical sciences › inorganic chemistry › alkali metals
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › protein folding
• medical and health sciences › basic medicine › physiology

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

WEIZMANN INSTITUTE OF SCIENCE

Address

Herzel Street, 2
76100 Rehovot
Israel

Participants (5)

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

Address

Batiment 152, Cea/saclay
91191 Gif Sur Yvette

LUND UNIVERSITY

Sweden

Address

Wallenberglaboratoriet, Ingang 46
205 02 Malmoe

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Israel

Address

Efron Street 7
31096 Haifa

TEL AVIV UNIVERSITY

Israel

Address

Ramat Aviv
69987 Tel Aviv

UNIVERSITY COLLEGE LONDON

United Kingdom

Address

Gower Street
London

Links