Objective
This proposal is focused on the use of conopeptide scaffolds for discovery and engineering of novel analgesics. A combination of polemic and selection methodologies will be used to identify conopeptide legends for receptors of clinical importance in chronic and naturopathic pain syndromes, namely the SNS tetrodotoxin-resistant sodium channel, and the p75 neurotrophin receptor. The multidisciplinary research program combines efforts of seven academic and two industrial groups, working in fields that include protein chemistry, protein folding and engineering, functional genomic, interaction selection systems, molecular physiology of pain pathways, and CNS delivery mechanisms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural scienceschemical sciencesinorganic chemistryalkali metals
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein folding
- medical and health sciencesbasic medicinephysiology
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
76100 REHOVOT
Israel