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From conopeptide scaffolds to analgesic leads

Objective

This proposal is focused on the use of conopeptide scaffolds for discovery and engineering of novel analgesics. A combination of polemic and selection methodologies will be used to identify conopeptide legends for receptors of clinical importance in chronic and naturopathic pain syndromes, namely the SNS tetrodotoxin-resistant sodium channel, and the p75 neurotrophin receptor. The multidisciplinary research program combines efforts of seven academic and two industrial groups, working in fields that include protein chemistry, protein folding and engineering, functional genomic, interaction selection systems, molecular physiology of pain pathways, and CNS delivery mechanisms.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

WEIZMANN INSTITUTE OF SCIENCE
Address
Herzel Street, 2
76100 Rehovot
Israel

Participants (5)

COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Batiment 152, Cea/saclay
91191 Gif Sur Yvette
LUND UNIVERSITY
Sweden
Address
Wallenberglaboratoriet, Ingang 46
205 02 Malmoe
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Address
Efron Street 7
31096 Haifa
TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
69987 Tel Aviv
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London