From conopeptide scaffolds to analgesic leads

Informazioni relative al progetto

CONO-EURO-PAIN

ID dell’accordo di sovvenzione: QLK3-CT-2000-00204

Progetto chiuso

Data di avvio 1 Febbraio 2001

Data di completamento 31 Gennaio 2004

Finanziato da

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Costo totale € 1 946 017,00

Contributo UE € 1 626 283,00

Coordinato da

WEIZMANN INSTITUTE OF SCIENCE
Israel

Obiettivo

This proposal is focused on the use of conopeptide scaffolds for discovery and engineering of novel analgesics. A combination of polemic and selection methodologies will be used to identify conopeptide legends for receptors of clinical importance in chronic and naturopathic pain syndromes, namely the SNS tetrodotoxin-resistant sodium channel, and the p75 neurotrophin receptor. The multidisciplinary research program combines efforts of seven academic and two industrial groups, working in fields that include protein chemistry, protein folding and engineering, functional genomic, interaction selection systems, molecular physiology of pain pathways, and CNS delivery mechanisms.

Campo scientifico

• natural sciences › chemical sciences › inorganic chemistry › alkali metals
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › protein folding
• medical and health sciences › basic medicine › physiology

Programma(i)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Argomento(i)

• 1.1.1.-3. - Key action The "Cell factory"

Invito a presentare proposte

Data not available

Meccanismo di finanziamento

CSC - Cost-sharing contracts

Coordinatore

WEIZMANN INSTITUTE OF SCIENCE

• Contributo UE: Nessun dato
• Indirizzo: Herzel Street, 2 ; 76100 REHOVOT ; Israele
• Costo totale: Nessun dato

Partecipanti (5)

COMMISSARIAT A L'ENERGIE ATOMIQUE

Francia

• Contributo UE: Nessun dato
• Indirizzo: Batiment 152, CEA/SACLAY ; 91191 GIF SUR YVETTE
• Costo totale: Nessun dato

LUND UNIVERSITY

Svezia

• Contributo UE: Nessun dato
• Indirizzo: Wallenberglaboratoriet, ingang 46 ; 205 02 MALMOE
• Costo totale: Nessun dato

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Israele

• Contributo UE: Nessun dato
• Indirizzo: Efron Street 7 ; 31096 HAIFA
• Costo totale: Nessun dato

TEL AVIV UNIVERSITY

Israele

• Contributo UE: Nessun dato
• Indirizzo: Ramat Aviv ; 69987 TEL AVIV
• Costo totale: Nessun dato

UNIVERSITY COLLEGE LONDON

Regno Unito

• Contributo UE: Nessun dato
• Indirizzo: Gower Street ; LONDON
• Costo totale: Nessun dato