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New anti-inflammatory natural products from medicinal plants using inducible transcription factors and their signalling pathways as molecular targets

Objective

The consortium assembled here will contribute to the development of new anti-inflammatory drugs for clinical use in the European Union and beyond by identifying medicinal plant extracts with NF-kappa inhibitory activity and/or inhibitory effects on targets of the inflammatory cascade in peripheral and CNStissues. These targets will include, for example, IL-1beta, TNFalpha, PGE2, and IL-6. Subsequently the compounds mediating this inhibitory effect will be isolated and their structure elucidated. The consortium has the capacity to evaluate the extracts in a large set of targets related to the transcriptional activation of gene products of relevance for inflammatory, immunomodulatory and apoptotic activity. Select compounds will be further studied in in-vivo as well as in-Microsystems and we expect that this research will form the basis for preclinical and clinical development.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF LONDON
Address
Malet Street, Senate House
WC1E7HU London
United Kingdom

Participants (7)

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LIMITED
United Kingdom
Address
Gunnels Wood Road, Medicines Research Centre
SG1 2NY Stevenage
THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORITY FOR RESEARCH AND DEVELOPMENT
Israel
Address
Ein Kerem Campus
91905 Jerusalem
UNIVERSIDAD DE CORDOBA
Spain
Address
Avda Menendez Pidal S/n
14004 Cordoba
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE 'AMEDEO AVOGADRO'
Italy
Address
Via Ferrucci 33
28100 Novara
UNIVERSITAETSKLINIKUM FREIBURG
Germany
Address
Hauptstr. 5
79104 Freiburg (In Breisgau)
UNIVERSITY OF BERNE
Switzerland
Address
3,Freiestrasse 3
3012 Bern
UNIVERSITY OF KUOPIO
Finland
Address
2,Neulaniementie 2
70211 Kuopio