Obiettivo The consortium assembled here will contribute to the development of new anti-inflammatory drugs for clinical use in the European Union and beyond by identifying medicinal plant extracts with NF-kappa inhibitory activity and/or inhibitory effects on targets of the inflammatory cascade in peripheral and CNStissues. These targets will include, for example, IL-1beta, TNFalpha, PGE2, and IL-6. Subsequently the compounds mediating this inhibitory effect will be isolated and their structure elucidated. The consortium has the capacity to evaluate the extracts in a large set of targets related to the transcriptional activation of gene products of relevance for inflammatory, immunomodulatory and apoptotic activity. Select compounds will be further studied in in-vivo as well as in-Microsystems and we expect that this research will form the basis for preclinical and clinical development. Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-3. - Key action The "Cell factory" Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF LONDON Contributo UE Nessun dato Indirizzo MALET STREET, SENATE HOUSE WC1E7HU LONDON Regno Unito Mostra sulla mappa Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LIMITED Regno Unito Contributo UE Nessun dato Indirizzo Gunnels Wood Road, Medicines Research Centre SG1 2NY STEVENAGE Mostra sulla mappa Costo totale Nessun dato THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORITY FOR RESEARCH AND DEVELOPMENT Israele Contributo UE Nessun dato Indirizzo Ein Kerem Campus 91905 JERUSALEM Mostra sulla mappa Costo totale Nessun dato UNIVERSIDAD DE CORDOBA Spagna Contributo UE Nessun dato Indirizzo Avda Menendez Pidal s/n 14004 CORDOBA Mostra sulla mappa Costo totale Nessun dato UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE 'AMEDEO AVOGADRO' Italia Contributo UE Nessun dato Indirizzo Via Ferrucci 33 28100 NOVARA Mostra sulla mappa Costo totale Nessun dato UNIVERSITAETSKLINIKUM FREIBURG Germania Contributo UE Nessun dato Indirizzo Hauptstr. 5 79104 FREIBURG (IN BREISGAU) Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF BERNE Svizzera Contributo UE Nessun dato Indirizzo 3,Freiestrasse 3 3012 BERN Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF KUOPIO Finlandia Contributo UE Nessun dato Indirizzo 2,Neulaniementie 2 70211 KUOPIO Mostra sulla mappa Costo totale Nessun dato
