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Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes

Objective

Hyper solutes, compatible solutes from hyperthermophiles, are superior to their mesospheric counterparts in the preservation of the performance of a wide variety of biomaterials, ranging from proteins to whole cells, skin and artificial tissues. A major bottleneck for industrial applications of hyper solutes is the large-scale production at a competitive cost. The major goal of this project is the development of cell systems eternised for the production of mannosylglycerate; the most widely distributed hyper solute. Two strategies will be pursued:
i) engineering of expression and secretion systems in suitable hosts;
ii) optimisation of fermentation of natural producers. Trials will be conducted that will widen the range of application of mannosylglycerate. The involvement of industrial partners ensures that the results will reach end-users.

Call for proposal

Data not available

Coordinator

INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
Address
Avenida Da Republica, Estacao Agronomica Nacional
Oeiras
Portugal
 

Participants (8)

BITOP - GESELLSCHAFT FUER BIOTECHNISCHE OPTIMIERUNG
Germany
Address
Stockumer Straße 28
58453 Witten
 
CENTRO DE NEUROSCIENCIAS DE COIMBRA
Portugal
Address
Departamento De Zoologia, Universidade De Coimbra
3004-517 Coimbra
 
MICROBIOLOGICAL RESEARCH AUTHORITY
United Kingdom
Address
Porton Down
SP4 0JG Salisbury
 
TRATAMENTO DE AGUAS E BIOTECNOLOGIA LDA
Portugal
Address
Quinta De Santa Maria Theresa, Botequim
2815-148 Charneca Da Caparica / Costa Da Caparica
 
TUHH-TECHNOLOGIE GMBH
Germany
Address
Denickerstrasse 15
21073 Hamburg
 
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
Address
Via Mezzocannone 16
80134 Napoli
 
UNIVERSITAET KONSTANZ
Germany
Address
10,Universitaetsstrasse 10
78457 Konstanz
 
UNIVERSITY OF ABERDEEN
United Kingdom
Address
Institute Of Medical Sciences, Foresthill
AB25 2ZD Aberdeen