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The alternative splicing database- a novel tool to diagnose human disease

Objective

The consortium proposes to create a database that contains all alternatively spliced axons from human, mouse, rat and drosophilae. Both manual duration and an automated computer pipeline from public databases will create the database. Alternative splicing has been increasingly recognized a reason for human disease and we will therefore develop a DNA chip that contains codas of all the splicing regulatory proteins and their is forms, as well as a chip that contains a number of disease relevant genes. We will concentrate on three models of disease (breast cancer, FTDP-17, male infertility) in which a connection between misplacing and a pathological state has been observed. Finally, an industrial partner to demonstrate that a human disease and possibly a predisposition to it can be detected will manufacture these chips.

Call for proposal

Data not available

Coordinator

UNIVERSITY OF ERLANGEN-NUREMBERG
Address
Fahrstrasse 17
91054 Erlangen
 

Participants (4)

CENTER FOR GENOMIC REGULATION
Address
Passeig Maritim 37-49
08003 Barcelona
 
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Address
Meyerhofstrasse 1
69012 Heidelberg
 
EXONHIT THERAPEUTICS S.A.
Address
Boulevard Masséna, 65
75013 Paris
 
THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORITY FOR RESEARCH AND DEVELOPMENT
Address
Givat Ram Campus
91904 Jerusalem