Objetivo
The consortium proposes to create a database that contains all alternatively spliced axons from human, mouse, rat and drosophilae. Both manual duration and an automated computer pipeline from public databases will create the database. Alternative splicing has been increasingly recognized a reason for human disease and we will therefore develop a DNA chip that contains codas of all the splicing regulatory proteins and their is forms, as well as a chip that contains a number of disease relevant genes. We will concentrate on three models of disease (breast cancer, FTDP-17, male infertility) in which a connection between misplacing and a pathological state has been observed. Finally, an industrial partner to demonstrate that a human disease and possibly a predisposition to it can be detected will manufacture these chips.
Ámbito científico
Convocatoria de propuestas
Data not availableRégimen de financiación
DEM - Demonstration contractsCoordinador
91054 Erlangen
Alemania