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Molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke

Objective

- To study the effects of air pollution and Environmental Tobacco Smoke (ETS) on cancers of the lung, bladder, pharynx, and larynx, plus COPD emphysema in non-smokers in nine European countries. This will be done with a nested case-cohort design in the EPIC investigation (450000 volunteers already recruited), by the means of biomarkers to exposure and susceptibility. In total 1000 randomly chosen controls will be analysed.
- To assess exposure levels by expert interpretation of already available questionnaires plus objective information on air pollution in different European cities. Exposure to ETS will also be assessed by measuring cotinine in the blood.
- To assess the effect of dose and length of exposure to environmental polluants on biological endpoints, such as DNA and hemoglobin adducts. Hemoglobin and WBC-DNA adducts formed by nitropyrenes, PAHs and other environmental contaminants (mainly due to traffic pollution and occupational exposures) will be measured. The adduct technology allows at least a partial separation of different sources of exposure (nitroarene adducts refer mainly to diesel exhaust, 4-aminobiphenyl-hemoglobin adducts to active or Environmental Tobacco Smoke).
- To study the relationship between adducts and disease according to genotypes for metabolism of the relevant carcinogens and DNA according to a newly developed technique.
- To evaluate the prote

Coordinator

UNIVERSITY OF TORINO
Address
Via Giuseppe Verdi 8
10124 Torino (Turin)
Italy

Participants (8)

CENTRO PER LO STUDIO E LA PREVENZIONE ONCOLOGICA
Italy
Address
Viale A.volta 171
50131 Firenze
GENETICS RESEARCH INSTITUTE ONLUS
Italy
Address
Strada Della Carita 10
20135 Milano
INSTITUTE FOR SCIENTIFIC INTERCHANGE FOUNDATION I.S.I.
Italy
Address
Viale Settimo Severo 65
10133 Torino (Turin)
INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
France
Address
Cours Albert-thomas 150
Lyon
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH
Italy
Address
Via Eritrea 62
20157 Milano
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
Trinity Lane The Old Schools
CB2 1TS Cambridge
UNIVERSITY OF AARHUS
Denmark
Address
1,Nordre Ringgade 1-3
8000 Aarhus C
WORLD HEALTH ORGANIZATION.
Switzerland
Address
Avenue Appia 20
Geneve