Objective
- To study the effects of air pollution and Environmental Tobacco Smoke (ETS) on cancers of the lung, bladder, pharynx, and larynx, plus COPD emphysema in non-smokers in nine European countries. This will be done with a nested case-cohort design in the EPIC investigation (450000 volunteers already recruited), by the means of biomarkers to exposure and susceptibility. In total 1000 randomly chosen controls will be analysed.
- To assess exposure levels by expert interpretation of already available questionnaires plus objective information on air pollution in different European cities. Exposure to ETS will also be assessed by measuring cotinine in the blood.
- To assess the effect of dose and length of exposure to environmental polluants on biological endpoints, such as DNA and hemoglobin adducts. Hemoglobin and WBC-DNA adducts formed by nitropyrenes, PAHs and other environmental contaminants (mainly due to traffic pollution and occupational exposures) will be measured. The adduct technology allows at least a partial separation of different sources of exposure (nitroarene adducts refer mainly to diesel exhaust, 4-aminobiphenyl-hemoglobin adducts to active or Environmental Tobacco Smoke).
- To study the relationship between adducts and disease according to genotypes for metabolism of the relevant carcinogens and DNA according to a newly developed technique.
- To evaluate the prote
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- engineering and technology environmental engineering air pollution engineering
- medical and health sciences clinical medicine oncology
- natural sciences earth and related environmental sciences environmental sciences pollution
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
10124 TORINO (TURIN)
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.