Objective The goal of this proposal is to provide accurate, up-to-date data on occupational exposure to wood dust, and to assess associations between such exposure and molecular alterations of Sino-nasal cancers, and biological mechanisms of pulmonary inflammation. Data on overall levels of European exposure will be obtained from European exposure databases and exposure registers as well as by monitoring wood dust levels in workplaces. Sino-nasal cancer cases and their exposure histories will be collected and paraffin-embedded tissue samples examined for p53 and K-transmutations. DNA damage induced by wood dust will be studied in exposed human cells. Molecular mechanisms of wood dust-induced pulmonary inflammation will be studied with experimental animals and cell cultures, and with nasal epithelial cells obtained from wood dust exposed subjects. Data from exposure assessment and the toxicological endpoints will be compiled for risk assessment. The study ultimately aims to provide exposure and mechanism-bases data for setting occupational limit values to improve safety at workplaces. Fields of science natural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologyagricultural sciencesagriculture, forestry, and fisheriesforestry Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-4. - Key action Environment and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator FINNISH INSTITUTE OF OCCUPATIONAL HEALTH Address 41 a,topeliuksenkatu 41 a 00250 Helsinki Finland See on map EU contribution € 0,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 0,00 Address 14,rue du val d'osne 14 94410 St.maurice See on map NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH Denmark EU contribution € 0,00 Address Lersí parkalle 105 2100 Koepenhagen See on map NATIONAL REASEARCH AND SAFETY INSTITUTE FOR THE PREVENTION OF OCCUPATIONAL ACCIDENTS AND DISEASES France EU contribution € 0,00 Address Avenue de bourgogne 54501 Vandoeuvre-les-nancy See on map
