Obiettivo The goal of this proposal is to provide accurate, up-to-date data on occupational exposure to wood dust, and to assess associations between such exposure and molecular alterations of Sino-nasal cancers, and biological mechanisms of pulmonary inflammation. Data on overall levels of European exposure will be obtained from European exposure databases and exposure registers as well as by monitoring wood dust levels in workplaces. Sino-nasal cancer cases and their exposure histories will be collected and paraffin-embedded tissue samples examined for p53 and K-transmutations. DNA damage induced by wood dust will be studied in exposed human cells. Molecular mechanisms of wood dust-induced pulmonary inflammation will be studied with experimental animals and cell cultures, and with nasal epithelial cells obtained from wood dust exposed subjects. Data from exposure assessment and the toxicological endpoints will be compiled for risk assessment. The study ultimately aims to provide exposure and mechanism-bases data for setting occupational limit values to improve safety at workplaces. Campo scientifico natural sciencescomputer and information sciencesdatabaseshumanitieshistory and archaeologyhistorynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologyagricultural sciencesagriculture, forestry, and fisheriesforestry Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-4. - Key action Environment and Health Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore FINNISH INSTITUTE OF OCCUPATIONAL HEALTH Contributo UE Nessun dato Indirizzo 41 A,Topeliuksenkatu 41 A 00250 HELSINKI Finlandia Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo 14,Rue du Val d'Osne 14 94410 ST.MAURICE Mostra sulla mappa Costo totale Nessun dato NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH Danimarca Contributo UE Nessun dato Indirizzo Lersí Parkalle 105 2100 KOEPENHAGEN Mostra sulla mappa Costo totale Nessun dato NATIONAL REASEARCH AND SAFETY INSTITUTE FOR THE PREVENTION OF OCCUPATIONAL ACCIDENTS AND DISEASES Francia Contributo UE Nessun dato Indirizzo Avenue de Bourgogne 54501 VANDOEUVRE-LES-NANCY Mostra sulla mappa Costo totale Nessun dato