Skip to main content

Disregulation of endogenous steroid metabolism potentially alters neuronal and reproductive system development: effects of environmental plasticisers

Objective

Steroids not only regulate endocrine and reproductive systems, they also modulate neuronal development in the foetus and neonate and cognitive function in adults. ENDOMET aims to examine the effects of a range of endocrine disrupters (EDs), which are derived from industrially manufactured plasticisers (EPs). These Eps (Bisphenol-A, alkyl phenols, adipate and phthalate esters) are found in foods, which are processed or packaged with plastic materials and in dialysis and intravenous drip fluids as contaminants from the plastic tubing. They have teratogenic and feminising effects at low levels in rats and fish. ENDOMET will determine the effects of these Eps on steroid metabolism, steroid function and reproductive potential, using human cell lines and a proteomics/genomics approach. An in vitro range of biomarker tests will be derived to predict potential ED activity of chemical compounds in humans. Public perception of risk will be assessed and compared with that of experts.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF BIRMINGHAM
Address
Edgbaston
B15 2TT Birmingham
United Kingdom

Participants (4)

INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY - SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
Vlarska 3
833 06 Bratislava
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
6,Duesbergweg 6
55099 Mainz
UNIVERSITY OF AARHUS
Denmark
Address
180,Vennelyst Boulevard, 6
8000 Aarhus C
UNIVERSITY OF ULM
Germany
Address
8,Robert-koch-strasse 8
89081 Ulm