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Content archived on 2024-05-24

Disregulation of endogenous steroid metabolism potentially alters neuronal and reproductive system development: effects of environmental plasticisers

Objective

Steroids not only regulate endocrine and reproductive systems, they also modulate neuronal development in the foetus and neonate and cognitive function in adults. ENDOMET aims to examine the effects of a range of endocrine disrupters (EDs), which are derived from industrially manufactured plasticisers (EPs). These Eps (Bisphenol-A, alkyl phenols, adipate and phthalate esters) are found in foods, which are processed or packaged with plastic materials and in dialysis and intravenous drip fluids as contaminants from the plastic tubing. They have teratogenic and feminising effects at low levels in rats and fish. ENDOMET will determine the effects of these Eps on steroid metabolism, steroid function and reproductive potential, using human cell lines and a proteomics/genomics approach. An in vitro range of biomarker tests will be derived to predict potential ED activity of chemical compounds in humans. Public perception of risk will be assessed and compared with that of experts.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF BIRMINGHAM
EU contribution
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Address
Edgbaston
B15 2TT BIRMINGHAM
United Kingdom

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Total cost

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Participants (4)

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