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Disregulation of endogenous steroid metabolism potentially alters neuronal and reproductive system development: effects of environmental plasticisers

Objectif

Steroids not only regulate endocrine and reproductive systems, they also modulate neuronal development in the foetus and neonate and cognitive function in adults. ENDOMET aims to examine the effects of a range of endocrine disrupters (EDs), which are derived from industrially manufactured plasticisers (EPs). These Eps (Bisphenol-A, alkyl phenols, adipate and phthalate esters) are found in foods, which are processed or packaged with plastic materials and in dialysis and intravenous drip fluids as contaminants from the plastic tubing. They have teratogenic and feminising effects at low levels in rats and fish. ENDOMET will determine the effects of these Eps on steroid metabolism, steroid function and reproductive potential, using human cell lines and a proteomics/genomics approach. An in vitro range of biomarker tests will be derived to predict potential ED activity of chemical compounds in humans. Public perception of risk will be assessed and compared with that of experts.

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

UNIVERSITY OF BIRMINGHAM
Contribution de l’UE
Aucune donnée
Adresse
Edgbaston
B15 2TT BIRMINGHAM
Royaume-Uni

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Coût total
Aucune donnée

Participants (4)