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Disregulation of endogenous steroid metabolism potentially alters neuronal and reproductive system development: effects of environmental plasticisers

Ziel

Steroids not only regulate endocrine and reproductive systems, they also modulate neuronal development in the foetus and neonate and cognitive function in adults. ENDOMET aims to examine the effects of a range of endocrine disrupters (EDs), which are derived from industrially manufactured plasticisers (EPs). These Eps (Bisphenol-A, alkyl phenols, adipate and phthalate esters) are found in foods, which are processed or packaged with plastic materials and in dialysis and intravenous drip fluids as contaminants from the plastic tubing. They have teratogenic and feminising effects at low levels in rats and fish. ENDOMET will determine the effects of these Eps on steroid metabolism, steroid function and reproductive potential, using human cell lines and a proteomics/genomics approach. An in vitro range of biomarker tests will be derived to predict potential ED activity of chemical compounds in humans. Public perception of risk will be assessed and compared with that of experts.

Wissenschaftliches Gebiet

CORDIS klassifiziert Projekte mit EuroSciVoc, einer mehrsprachigen Taxonomie der Wissenschaftsbereiche, durch einen halbautomatischen Prozess, der auf Verfahren der Verarbeitung natürlicher Sprache beruht.

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UNIVERSITY OF BIRMINGHAM
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Vereinigtes Königreich

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