Objective The aim of our joint study is to investigate the roles of the neural cell adhesion molecules, NCAM and L1, in aged rodents with regard to the efficacy of acquisition, retention and recall of learned tasks versus that in young and adult animals. We wish to examine the contribution of the two molecules to synaptic plasticity using LTP in vitro and learning paradigms in vivo in wild type and transgenic animals. We also wish to characterise the functional properties of sub domain fragments of these molecules including their cognate legends and carbohydrates in modifying learning and memory. Further, we wish to identify novel legends of NCAM and L1 by means of rational design and combinatorial chemistry and to evaluate of such legends to preserve and promote the capacity for learning at old age and under stress. Fields of science natural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator N/A EU contribution No data Address See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address 31,Campus de Luminy 13288 MARSEILLE See on map Total cost No data NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland EU contribution No data Address Belfield 4 DUBLIN See on map Total cost No data SCHAFER-N Denmark EU contribution No data Address Fruebjerguej, 3 2100 KOEPENHAGEN See on map Total cost No data UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA Spain EU contribution No data Address Ciudad Universitaria s/n 28040 MADRID See on map Total cost No data UNIVERSITY OF COPENHAGEN Denmark EU contribution No data Address 3,Blegdamsvej 3C 2200 KOEPENHAGEN See on map Total cost No data