Obiettivo The aim of our joint study is to investigate the roles of the neural cell adhesion molecules, NCAM and L1, in aged rodents with regard to the efficacy of acquisition, retention and recall of learned tasks versus that in young and adult animals. We wish to examine the contribution of the two molecules to synaptic plasticity using LTP in vitro and learning paradigms in vivo in wild type and transgenic animals. We also wish to characterise the functional properties of sub domain fragments of these molecules including their cognate legends and carbohydrates in modifying learning and memory. Further, we wish to identify novel legends of NCAM and L1 by means of rational design and combinatorial chemistry and to evaluate of such legends to preserve and promote the capacity for learning at old age and under stress. Campo scientifico natural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-6. - Key action The Ageing Population and Disabilities Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore N/A Contributo UE Nessun dato Indirizzo Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo 31,Campus de Luminy 13288 MARSEILLE Mostra sulla mappa Costo totale Nessun dato NATIONAL UNIVERSITY OF IRELAND, DUBLIN Irlanda Contributo UE Nessun dato Indirizzo Belfield 4 DUBLIN Mostra sulla mappa Costo totale Nessun dato SCHAFER-N Danimarca Contributo UE Nessun dato Indirizzo Fruebjerguej, 3 2100 KOEPENHAGEN Mostra sulla mappa Costo totale Nessun dato UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA Spagna Contributo UE Nessun dato Indirizzo Ciudad Universitaria s/n 28040 MADRID Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF COPENHAGEN Danimarca Contributo UE Nessun dato Indirizzo 3,Blegdamsvej 3C 2200 KOEPENHAGEN Mostra sulla mappa Costo totale Nessun dato
