Objective
The experimental approach and different levels of analysis is aimed at understanding the molecular and cellular early phases of the neurodegeneration in Alzheimer's disease. This is not possible in humans and requires animal models that allow invasive analysis. Transgenic mice expressing human AD related genes (APP, PS1, Ape) have been and continue to be generated and will be validated. They will extend and recapitulate new findings in less complex systems, implemented in this proposal. "Multiple" transgenic mouse strains with more than one human transgenic are expected to show more complete pathology. Most important aspect addressed will be fundamental aspects of amyloidogenesis relating to the role of Personalise and its path physiological sequels on cognition, behaviour, neuropathology, oxidative stress, calcium homeostasis, protein degradation and modifying proteins.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological scienceszoologymammalogyprimatology
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesbasic medicinepathology
- medical and health sciencesbasic medicinephysiologyhomeostasis
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
3000 LOUVAIN / LEUVEN
Belgium