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Intervertebral disc degeneration : interplay of ageing, environmental and genetic factors (EURODISC)

Objective

Intervertebral disc degeneration is strongly associated with back pain, sciatica and other spinal disorders including spinal stenos is, a major cause of pain and disability in the elderly. These crippling disorders affect a large proportion of the population and around ten percent of cases become chronically ill. The costs of these disorders are immense; estimated at 1.7% of GNP in the Netherlands. Degeneration arises from a complex interplay between ageing, genetic susceptibility and life-style factors. We will investigate relationships between changes in the mechanical environment, cellular activity and tissue breakdown in relation to degeneration-associated polymorphisms and examine the relationship between genetics and environment in a classic twin study.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
Parks Road
OX1 3PT Oxford
United Kingdom

Participants (6)

EINDHOVEN UNIVERSITY OF TECHNOLOGY
Netherlands
Address
Den Dolech 2
5600 MB Eindhoven
NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS'
Greece
Address
Patriarchou Grogoriou
15310 Athens
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Address
Technion City
Haifa
THE ROBERT JONES AND AGNES HUNT ORTHOPAEDIC AND DISTRICT HOSPITAL NHS TRUST
United Kingdom
Address
Shrophsire
SY10 7AG Oswestry
UNIVERSITAETSKLINIKUM ULM
Germany
Address
Helmholtzstrasse 14
89081 Ulm
UNIVERSITY OF HELSINKI
Finland
Address
Mannerhermintie
00014 Helsinki