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Intervertebral disc degeneration : interplay of ageing, environmental and genetic factors (EURODISC)

Objetivo

Intervertebral disc degeneration is strongly associated with back pain, sciatica and other spinal disorders including spinal stenos is, a major cause of pain and disability in the elderly. These crippling disorders affect a large proportion of the population and around ten percent of cases become chronically ill. The costs of these disorders are immense; estimated at 1.7% of GNP in the Netherlands. Degeneration arises from a complex interplay between ageing, genetic susceptibility and life-style factors. We will investigate relationships between changes in the mechanical environment, cellular activity and tissue breakdown in relation to degeneration-associated polymorphisms and examine the relationship between genetics and environment in a classic twin study.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Dirección
Parks Road
OX1 3PT Oxford
United Kingdom

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Participantes (6)

EINDHOVEN UNIVERSITY OF TECHNOLOGY
Países Bajos
Dirección
Den Dolech 2
5600 MB Eindhoven

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NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS'
Grecia
Dirección
Patriarchou Grogoriou
15310 Athens

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TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Dirección
Technion City
Haifa

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THE ROBERT JONES AND AGNES HUNT ORTHOPAEDIC AND DISTRICT HOSPITAL NHS TRUST
United Kingdom
Dirección
Shrophsire
SY10 7AG Oswestry

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UNIVERSITAETSKLINIKUM ULM
Alemania
Dirección
Helmholtzstrasse 14
89081 Ulm

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UNIVERSITY OF HELSINKI
Finlandia
Dirección
Mannerhermintie
00014 Helsinki

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