Intervertebral disc degeneration : interplay of ageing, environmental and genetic factors (EURODISC)

Ziel

Intervertebral disc degeneration is strongly associated with back pain, sciatica and other spinal disorders including spinal stenos is, a major cause of pain and disability in the elderly. These crippling disorders affect a large proportion of the population and around ten percent of cases become chronically ill. The costs of these disorders are immense; estimated at 1.7% of GNP in the Netherlands. Degeneration arises from a complex interplay between ageing, genetic susceptibility and life-style factors. We will investigate relationships between changes in the mechanical environment, cellular activity and tissue breakdown in relation to degeneration-associated polymorphisms and examine the relationship between genetics and environment in a classic twin study.

Wissenschaftliches Gebiet

• Naturwissenschaften › Biowissenschaften › Genetik

Programm/Programme

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Thema/Themen

• 1.1.1.-6. - Key action The Ageing Population and Disabilities

Aufforderung zur Vorschlagseinreichung

Data not available

Finanzierungsplan

CSC - Cost-sharing contracts

Koordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Adresse

Parks Road
OX1 3PT Oxford
United Kingdom

Beteiligte (6)

EINDHOVEN UNIVERSITY OF TECHNOLOGY

Niederlande

Adresse

Den Dolech 2
5600 MB Eindhoven

NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS'

Griechenland

Adresse

Patriarchou Grogoriou
15310 Athens

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Israel

Adresse

Technion City
Haifa

Links

THE ROBERT JONES AND AGNES HUNT ORTHOPAEDIC AND DISTRICT HOSPITAL NHS TRUST

United Kingdom

Adresse

Shrophsire
SY10 7AG Oswestry

UNIVERSITAETSKLINIKUM ULM

Deutschland

Adresse

Helmholtzstrasse 14
89081 Ulm

UNIVERSITY OF HELSINKI

Finnland

Adresse

Mannerhermintie
00014 Helsinki