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Intervertebral disc degeneration : interplay of ageing, environmental and genetic factors (EURODISC)

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Intervertebral disc degeneration is strongly associated with back pain, sciatica and other spinal disorders including spinal stenos is, a major cause of pain and disability in the elderly. These crippling disorders affect a large proportion of the population and around ten percent of cases become chronically ill. The costs of these disorders are immense; estimated at 1.7% of GNP in the Netherlands. Degeneration arises from a complex interplay between ageing, genetic susceptibility and life-style factors. We will investigate relationships between changes in the mechanical environment, cellular activity and tissue breakdown in relation to degeneration-associated polymorphisms and examine the relationship between genetics and environment in a classic twin study.

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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Parks Road
OX1 3PT Oxford
Vereinigtes Königreich

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Letzte Aktualisierung: 12 April 2005

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Permalink: https://cordis.europa.eu/project/id/QLK6-CT-2002-02582/de

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