Skip to main content

Intervertebral disc degeneration : interplay of ageing, environmental and genetic factors (EURODISC)

Ziel

Intervertebral disc degeneration is strongly associated with back pain, sciatica and other spinal disorders including spinal stenos is, a major cause of pain and disability in the elderly. These crippling disorders affect a large proportion of the population and around ten percent of cases become chronically ill. The costs of these disorders are immense; estimated at 1.7% of GNP in the Netherlands. Degeneration arises from a complex interplay between ageing, genetic susceptibility and life-style factors. We will investigate relationships between changes in the mechanical environment, cellular activity and tissue breakdown in relation to degeneration-associated polymorphisms and examine the relationship between genetics and environment in a classic twin study.

Aufforderung zur Vorschlagseinreichung

Data not available

Koordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Adresse
Parks Road
OX1 3PT Oxford
United Kingdom

Auf der Karte ansehen

Links

Beteiligte (6)

EINDHOVEN UNIVERSITY OF TECHNOLOGY
Niederlande
Adresse
Den Dolech 2
5600 MB Eindhoven

Auf der Karte ansehen

Links
NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS'
Griechenland
Adresse
Patriarchou Grogoriou
15310 Athens

Auf der Karte ansehen

Links
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Adresse
Technion City
Haifa

Auf der Karte ansehen

THE ROBERT JONES AND AGNES HUNT ORTHOPAEDIC AND DISTRICT HOSPITAL NHS TRUST
United Kingdom
Adresse
Shrophsire
SY10 7AG Oswestry

Auf der Karte ansehen

Links
UNIVERSITAETSKLINIKUM ULM
Deutschland
Adresse
Helmholtzstrasse 14
89081 Ulm

Auf der Karte ansehen

Links
UNIVERSITY OF HELSINKI
Finnland
Adresse
Mannerhermintie
00014 Helsinki

Auf der Karte ansehen

Links