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Content archived on 2024-05-24

Intervertebral disc degeneration : interplay of ageing, environmental and genetic factors (EURODISC)

Objective

Intervertebral disc degeneration is strongly associated with back pain, sciatica and other spinal disorders including spinal stenos is, a major cause of pain and disability in the elderly. These crippling disorders affect a large proportion of the population and around ten percent of cases become chronically ill. The costs of these disorders are immense; estimated at 1.7% of GNP in the Netherlands. Degeneration arises from a complex interplay between ageing, genetic susceptibility and life-style factors. We will investigate relationships between changes in the mechanical environment, cellular activity and tissue breakdown in relation to degeneration-associated polymorphisms and examine the relationship between genetics and environment in a classic twin study.

Fields of science (EuroSciVoc)

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Topic(s)

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Call for proposal

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Funding Scheme

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Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
EU contribution
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Parks Road
OX1 3PT Oxford
United Kingdom

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Total cost

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Participants (6)

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