Objective Intervertebral disc degeneration is strongly associated with back pain, sciatica and other spinal disorders including spinal stenos is, a major cause of pain and disability in the elderly. These crippling disorders affect a large proportion of the population and around ten percent of cases become chronically ill. The costs of these disorders are immense; estimated at 1.7% of GNP in the Netherlands. Degeneration arises from a complex interplay between ageing, genetic susceptibility and life-style factors. We will investigate relationships between changes in the mechanical environment, cellular activity and tissue breakdown in relation to degeneration-associated polymorphisms and examine the relationship between genetics and environment in a classic twin study. Fields of science natural sciencesbiological sciencesgenetics Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Address Parks road OX1 3PT Oxford United Kingdom See on map EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all EINDHOVEN UNIVERSITY OF TECHNOLOGY Netherlands EU contribution € 0,00 Address Den dolech 2 5600 MB Eindhoven See on map NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS' Greece EU contribution € 0,00 Address Patriarchou grogoriou 15310 Athens See on map TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israel EU contribution € 0,00 Address Technion city Haifa See on map Links Website Opens in new window THE ROBERT JONES AND AGNES HUNT ORTHOPAEDIC AND DISTRICT HOSPITAL NHS TRUST United Kingdom EU contribution € 0,00 Address Shrophsire SY10 7AG Oswestry See on map UNIVERSITAETSKLINIKUM ULM Germany EU contribution € 0,00 Address Helmholtzstrasse 14 89081 Ulm See on map UNIVERSITY OF HELSINKI Finland EU contribution € 0,00 Address Mannerhermintie 00014 Helsinki See on map
