Objective This proposal enhances infrastructure provision for the efficient exploitation of rodent models leading to the identification of genes and their biological validation. These genes and pathways are then potential targets for therapeutic intervention. The key areas for development are: Discovery of rat and mouse Snips and construction of mapping panel coupled with the development of very high throughput SNP genotyping technology based on mass spectrometry resulting in more efficient QTL mapping. Mouse cosmic panel and associated resource generation to facilitate QTL refinement mapping. Cross species and specialised tissue expression profiling to identify genes underlying Atlas and the pathways relevant to these traits. Comparative, QTL and Pathway gene maps to facilitate correlation with Atlas mapped in different species (Human, rat and mouse). Genotype driven recovery of an ENU allelic series in mouse to functionally validate genes of interest. Fields of science natural sciencesbiological sciencesgeneticsnatural scienceschemical sciencesanalytical chemistrymass spectrometry Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-14. - Support for research infrastructures Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator MEDICAL RESEARCH COUNCIL Address Harwell OX11 0RD Didcot,harwell,chilton United Kingdom See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSORTIUM NATIONAL DE RECHERCHE EN GÉNOMIQUE France EU contribution € 0,00 Address Rue gaston cremieux, 2 91057 Evry See on map INSTITUTE OF MOLECULAR GENETICS - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Czechia EU contribution € 0,00 Address Videnska 1083 142 20 Praha 4 See on map MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution € 0,00 Address 73,ihnestraße 73 14195 Berlin See on map THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 0,00 Address Roosevelt drive OX3 7BN Oxford/headington See on map UNIVERSITY OF LEICESTER United Kingdom EU contribution € 0,00 Address Groby road glenfield general hospital clinical sc LE3 9QP Leicester See on map
