Objective
Vascular endothelial cells have multiple functions: they
provide a non-thrombogenic surface, control microvascular
permeability, release factors which inhibit platelet
activation and relax vascular smooth muscle (prostacyclin,
nitric oxide) and modulate the proliferation of vascular -
smooth muscle cells... The concentration of cytosolic Ca2+
plays a crucial role in the control of several of these
functions: a rise of cytosolic Ca2+ stimulates the release
of prostacyclin and nitric oxide and induces cell
contraction, resulting in an increased permeability. More
recently, the potential importance of cyclic AMP in the
control of endothelial cell functions has emerged. Cyclic
AMP inhibits endothelial cell contraction and enhances the
barrier property of the endothelium. It stimulates the
expression of thrombomodulin on the surface of endothelial
cells, amplifies the release of tissue-plasminogen
activator (t-PA) and inhibits the secretion of an inhibitor
of t-PA. It also inhibits the synthesis of an endothelial
form of platelet-derived growth factor (PDGF). Therefore
it seems that agents which would increase the level of
cyclic AMP in endothelial cells might have a therapeutic
potential, in various pathological conditions. Enhancement
of barrier properties will decrease inflammatory exudates.
The stimulation of anticoagulant and fibrinolytic
mechanisms would be beneficial for the prevention of
thrombosis. Finally, the inhibition of PDGF synthesis
could be of value for the prevention of atherosclerosis.
The purpose of the present project is to investigate in
greater detail the mechanisms which control the level of
cyclic AMP in vascular endothelial cells - in particular
the role of H2 and P2 receptors - as well as the functional
consequences of increases in cyclic AMP level, in
particular on endothelial cell proliferation and on the
release of prostacyclin.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1070 BRUXELLES
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.