Objective
IN AN AREA 0F HIGH CATTLE DENSITY, THE ENDEMICITY 0F HUMAN ONCHOCERCIASIS WAS REMARKABLY LOW, DESPITE HIGH SIMULIUM-SQUAMOSUM BITING RATES AND ONCHOCERCA TRANSMISSION POTENTIALS, MAINLY 0F L3 FROM ONCHOCERCA OCHENGI OF CATTLE. THIS PROMPTS US TO INVESTIGATE THE POTENTIAL USE 0F NON-HUMAN BLOODHOSTS ('ZOOPROPHYLAXIS') AS A MEANS OF COMBINING RURAL DEVELOPMENT WITH CONTROL 0F HUMAN DISEASE. CATTLE AND OTHER LIFESTOCK ANIMALS WOULD CONSTITUTE AN APPARENTLY VERY WELL ACCEPTED SUBSTITUTION FOR THE HUMAN BLOOD To THE FLIES. THIS REDUCES THE VECTORIAL CAPACITY OF SIMULIUM POPULATIONS STRONGLY (H2).
AN ADDITIONAL PROTECTION MAY BE AFFORDED BY THE INVASIVE LARVAE OF O;OCHENGI, WHICH PROBABLY INVADE THE HUMAN HOST AND STIMULATE THE IMMUNE SYSTEM So THAT THE SURVIVAL IS REDUCED FOR SUBSEQUENT INADING LARVAE OF 0. VOLVULUS. ANTIGENS 0F INVADING AND OF IN-VITRO CULTURED L3 WILL BE SCREENED FOR RECOGNITION BY HUMAN AND CATTLE SERA FROM AREAS WITH AND WITHOUT HUMAN AND BOVINE ONCHOCERCIASIS. CROSSREACTIVE ANTIGENS WILL BE TESTED FOR THEIR IMMUNOGENICITY.
THE RESULTS OF THIS STUDY MAY HELP TO DEVELOP LOCAL STRATEGIES FOR INTEGRATED ONCHOCERCIASIS CONTROL, WHICH COMBINE THE NEED OF DISEASE CONTROL WITH LIFESTOCK PRODUCTION AND SOCIO-ECONOMIC DEVELOPMENT OF RURAL AREAS.
THE EXISTING EXPERTISE 0F AN ON-GOING EPIDEMIOLOGICAL STUDY
CARRIED OUT BY COLLABORATING INSTITUTIONS FROM CAMEROON AND TÜBINGEN WILL BE LINKED TO MODERN METHODS OF IMMUNOLOGY AND MOLECULAR BIOLOGY AVAILABLE IN GLASGOW AND TÜBINGEN THIS COLLABORATION SHALL BE EXTENDED BY INCLUDING A PARTNER FROM NIGERIA, WHERE A NATIONAL ONCHOCERCIASIS CONTROL PROGRAMME IS ENVISAGED:
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- agricultural sciences animal and dairy science domestic animals animal husbandry
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
70599 STUTTGART
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.