Objective
THE STUDY WILL BE A MULTIDISCIPLINARY COLLABORATION BETWEEN SCIENTISTS OF THE UNIVERSIDADE DE LUANDA "AGOSTINHO NETO", ANGOLA, THE INTERUNIVERSITY RESEARCH CENTRE ON DEVELOPING COUNTRIES (CIRPS), ITALY, THE LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE (LSHTM), UNITED KINGDOM, AND OF A SOMALI TEAM (AT PRESENT CIRPS-LSHTM) OF THE SOMALI NATIONAL UNIVERSITY. A SYNCRETIC APPROACH WILL BE ADOPTED WHEREBY QUALITATIVE AND QUANTITATIVE DATA ARE COLLECTED INTERFACING VARIOUS DISCIPLINES SUCH AS EPIDEMILOGY, SOCIAL AND BEHAVIOURAL SCIENCES, BACTERIAL GENETICS AND MOLECULAR BIOLOGY. THIS MULTIDISCIPLINARY APPROACH WILL ATTEMPT TO IDENTIFY FACTORS TRIGGERING THE EPIDEMIC PHASES IN AN ENDEMIC AREA AND DETERMINANTS OF EFFECTIVE TRANSMISSION BY DEFINING LINKS BETWEEN HOUSEHOLD STRUCTURE (THE STUDY UNIT), BEHAVIOURAL PATTERNS WITHIN THE HOUSEHOLD ENVIRONMENTAL CHARACTERISTICS AND ROUTES OF INFECTION PROPAGATION. GENETIC TOOLS BASED ON MARKERS SUCH AS PLASMIDS, VIBRIOPHAGES/INTEGRATION SITES, REPEATED GENOMIC DNA SEQUENCES WILL BE DEVELOPED TO RECONSTRUCT HISTORY AND TRACE DIFFERENT PREVALENT INDIVIDUAL STRAINS OF VIBRIO CHOLERAE 01. MOLECULAR PROCEDURES OF SPECIFIC DNA AMPLIFICATION WILL BE ESTABLISHED TO DIRECTLY DETECT SMALL NUMBERS OF VIBRIO CHOLERAE 01 BACTERIO IN HUMAN AND ENVIRONMENTAL SPECIMENS. THE MAIN INTEGRATED OBJECTIVE IS TO RESOLVE THE INFECTION PROPAGATION INTO ITS SINGLE STEPS AND DESIGN A DYNAMIC MODEL TO PROVIDE A BETTER UNDERSTANDING OF CHOLERA TRANSMISSION AND TO PROPOSE MORE ADEQUATE, MULTISECTORAL CHOLERA CONTROL STRATEGIES.
QUANTITATIVE INFORMATION ON CHOLERA MORBIDITY, ANTHROPOMETRIC STATUS OF ADULTS AND CHILDREN HEALTH SYSTEMS UTILIZATION, AND ON PATTERNS OF HYGIENIC AND FOOD HANDLING BEHAVIOURS WILL BE COLLECTED BY ACTIVE SURVEILLANCE AND OBSERVATIONS DURING A PERIOD OF 20 MONTHS. A FOLLOW-UP OF A SAMPLE OF HOUSEHOLDS (100-300 PER COMMUNITY) IN SMALL TO MEDIUM-SIZE URBAN COMMUNITIES (4-6) OF THE ANGOLAN COASTAL REGION WILL BE PERFORMED. QUALITATIVE DATA ON BELIEFS AND KNOWLEDGE ABOUT CHOLERA, ON DETERMINANTS OF AND CONSTRAINTS TO THE ADOPTION OF HYGIENIC BEHAVIOURS, AND ON DEVELOPMENT PRIORITIES WILL BE COLLECTED IN THE STUDY COMMUNITIES. THE DISTRIBUTION AND THE HISTORY OF V. CHOLERAE 01 STRAINS IN THE STUDY POPULATION AND IN THE ENVIRONMENT WILL BE CHARACTERISED IN DETAIL BY THE MOLECULAR AND GENETIC ANALYSIS.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences tropical medicine
- humanities history and archaeology history
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00184 ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.