Objective
THIS PROJECT WILL INVESTIGATE THE DEVELOPMENT OF IMMUNITY TO THE ERYTHROCYTIC STAGES OF THE MALARIA PARASITE, PLASMODIUM FALCIPARUM, WITHIN A DEFINED ENDEMIC AREA IN BENIN, WEST AFRICA. THE SPECIFICITY AND FUNCTION OF RESPONDING T CELLS WILL BE STUDIED WITH REFERENCE TO RESPONSES WHICH CORRELATE WITH THE DEVELOPMENT EITHER OF THE PATHOLOGY OF THIS DISEASE OR WITH PROTECTIVE IMMUNITY. THE PHERNOTYPE AND FUNCTION OF T CELLS RESPONDING TO ENTIGENS OF P. FALCIPARUM WILL BE COMPARED AMONGST INDIVIDUALS OF DIFFERING AGE, DISEASE AND IMMUNE STATUS. THESE INDIVIDUALS WILL ALSO BE STUDIED FOR THEIR RESPONSES TO SELECTED DEFINED ANTIGENS (MSA-1, MSA-2, AMA-1 AND S-ANTIGENS) AND TO OTHER PROTEINS OF THE PARASITES. THE EFFECTS OF IMMUNE PRESSURE ON VARIABILITY ON THESE ANTIGENS WILL BE INVESTIGATED TOGETHER WITH A STUDY OF THE PEPTIDES WHICH ARE PREESENTED TO T CELLS. THIS WILL DETERMINE WHETHER THE PEPTIDES RECOGNISED BY IMMUNE CELLS ARE THOSE AFFECTED BY IMMUNE PRESSURE AND WHETHER THESE ANTIGENS ARE SUITABLE CANDIDATES FOR INCORPORATION IN A MALARIA VACCINE.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
projects.no_data
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
projects.no_data
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
79108 Freiburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.