Objective
This grant application proposes the development of a broadly protective pneumococcal vaccine, also effective in infants and with the aim of making such a vaccine available to the developing world.
Pneumococcal infections are a main cause of mortality associated with acute respiratory infections(Arl) and prevention by vaccination would be the most effective and less costly approach to combat such serious cases of ARI. In order to develop this vaccine, a number of national public health institutes from Finland, Sweden, Norway, Denmark, The Netherlands and The
Philippines with specific expertise in vaccinology have joint their forces. Collaboration ensures the availability of the necessary technical expertise and an open collaboration with and transfer of technology to developing countries without unnecessary barriers such as profit making, secrecy and developmental cost implementation.
Together the group of institutes combine the areas of basic research up to vaccine production and field evaluation. The project focuses on the development of a multivalent polysaccharide-protein conjugate vaccine. The well establisshed pneumococcal-protective-antigens, the capsular polysaccharides, demonstrate the typical immunological shortcomings of such antigens, i.e. T-independent nature (no memory, no response in infants). pneumococci can be subdivided into over 80 capsular polysaccharide serotypes, a further complication.
We propose to develop a multivalent polysaccharide-protein conjugate vaccine containing at least the most prevalent invasive polysaccharide types, 1, 5, 6B, 14, 19F, 23F, according to principles that made Haemophilus influenzae type b conjugate succesful.
This project encompasses the development of the wanted vaccine up to phase 1 and 2 clinical trials for side-effects and potencv, to be carried out in Finland and The Philippines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- social sciences sociology demography mortality
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules carbohydrates
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3720 BA Bilthoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.