Objective
This project aims to develop simple, robust, cheap, on-farm antibody assays specific to Babesia-bovis and B.-bigemina which can be used to determine the immun e status of cattle to these organisms in southern and east Africa and aid the determination of herd levels of enzootic stability. This objective will be achieved by collaboration between laboratories in Liverpool, paris, Lisbon, Maputo and Harare, with the Faculties of Veterinary Science in Maputo and Veterinary parasitology, Liverpool School of Tropical Medicine/university of Liverpool as the principal sites. By exploiting newly developed serum-free culture techniques pioneered by the French collaborators, B. bovis and B.bigemina exoantigens will be characterised to determine species specific, non-strain specific antigens suitable for diagnostic use. These will be utilised in a solid phase, dipstick assay using colloidal dye labelled anti-immunoglobulin conjugates. The assay will be applied in field studies in zimbabwe and Mozambique to determine the prevalence and incidence of these infections. At the same time, the collection of field isolates of B. bovis will afford the opportunity to perform a preliminary investigation of cytoadherence in B. bovis, and by comparisons with plasmodium falciparum, to help elucidate the pathophysiology of cerebral babesiosis.
A major aim of the project is to provide training in the form of two PhDs, (one Mozambiquan, one portuguese) and training for technical staff in Maputo and Harare. The results of the project will be disseminated by training technicians from Malawi, Zambia and Kenya to enable preliminary applications of the results in those countries. It is hoped that the network of centres involved can form the basis of a continuing and expanding collaboration.
The development of a cheap on-farm assay for antibodies to Babesia spp. will facilitate the determination of herd immune status and the exploitation of enzootic stability to improve the control of babesiosis, with a more cost-effective use of acaricides and the potential for a targetted application of vaccinition.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences tropical medicine
- agricultural sciences veterinary sciences
- medical and health sciences health sciences parasitology
- medical and health sciences basic medicine physiology pathophysiology
- agricultural sciences animal and dairy science domestic animals animal husbandry
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
L3 5QA Liverpool
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.