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Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases

Objective

Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in joint space width (JSW). However, radiographic evidence is seen only after significant cartilage degradation has already taken place. The early stages of the disease may remain latent and asymptomatic for many years. Therefore, there is an acute need for reliable biomarkers and diagnostic tests that can facilitate earlier diagnosis of OA, and inform the prognosis, monitoring and therapeutic strategies for chronic and disabling forms of this disease. However, there is currently a lack of reliable, quantifiable and easily measured biomarkers that provide an earlier diagnosis of OA, inform on the prognostic of the disease and monitor and predict responses to therapeutic modalities. Biomarkers of tissue turnover in joints can reflect disease relevant biological activity and provide valuable information that may be useful diagnostically and therapeutically, potentially enabling a more rational and personalized approach to healthcare management. The proliferation of omic technologies has facilitated rapid progress in biomarker research. Combinations of omic technologies are dominating the biomarker research arena and are playing increasingly important roles in the identification, validation and qualification of new biomarkers. The aim of the D-BOARD consortium is to bring together leading academic institutions and European Small and Medium Enterprises (SMEs) to focus on the identification, validation and qualification of new combination biomarkers and the development of diagnostic tests capable of subclinical disease diagnosis for degenerative and inflammatory diseases of joints.

Field of science

  • /medical and health sciences/health sciences/inflammatory diseases

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITY OF SURREY
Address
Stag Hill
GU2 7XH Guildford
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 879 154,40
Administrative Contact
Maria Sega-Buhalis (Mrs.)

Participants (14)

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 519 273,90
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fiona Airey (Mrs.)
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 668 355
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Isabelle Halleux (Dr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 245 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hermannus Weinans (Prof.)
BIOMEDIQ AS
Denmark
EU contribution
€ 187 470
Address
Fruebjergvej 3
2100 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Camilla Jørgensen (Ms.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 363 643
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
Administrative Contact
Anne-Marie Zuurmond (Dr.)
Westfälische Wilhelms-Universität Münster
Germany
EU contribution
€ 360 000
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingo Niendorf (Mr.)
NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S
Denmark
EU contribution
€ 648 277
Address
Herlev Hovedgade 207
2730 Helev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Regitze Lausbak (Ms.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 336 720
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jane Turner (Ms.)
BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 403 200,77
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nagy Ildiko (Dr.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 171 230,39
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pam Neagle (Mrs.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 386 312
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gissela Rijn Van H.A (Ms.)
UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 50 000
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Volker Legewie (Mr.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 726 166,23
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
EDGELEAP B.V.
Netherlands
EU contribution
€ 48 656,40
Address
Hooghiemstraplein 15
3514AX Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marijana Radonjic (Dr.)