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Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases

Objective

Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in joint space width (JSW). However, radiographic evidence is seen only after significant cartilage degradation has already taken place. The early stages of the disease may remain latent and asymptomatic for many years. Therefore, there is an acute need for reliable biomarkers and diagnostic tests that can facilitate earlier diagnosis of OA, and inform the prognosis, monitoring and therapeutic strategies for chronic and disabling forms of this disease. However, there is currently a lack of reliable, quantifiable and easily measured biomarkers that provide an earlier diagnosis of OA, inform on the prognostic of the disease and monitor and predict responses to therapeutic modalities. Biomarkers of tissue turnover in joints can reflect disease relevant biological activity and provide valuable information that may be useful diagnostically and therapeutically, potentially enabling a more rational and personalized approach to healthcare management. The proliferation of omic technologies has facilitated rapid progress in biomarker research. Combinations of omic technologies are dominating the biomarker research arena and are playing increasingly important roles in the identification, validation and qualification of new biomarkers. The aim of the D-BOARD consortium is to bring together leading academic institutions and European Small and Medium Enterprises (SMEs) to focus on the identification, validation and qualification of new combination biomarkers and the development of diagnostic tests capable of subclinical disease diagnosis for degenerative and inflammatory diseases of joints.
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Coordinator

UNIVERSITY OF SURREY

Address

Stag Hill
Gu2 7xh Guildford

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 879 154,40

Administrative Contact

Maria Sega-Buhalis (Mrs.)

Participants (14)

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UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU Contribution

€ 519 273,90

UNIVERSITE DE LIEGE

Belgium

EU Contribution

€ 668 355

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 245 000

BIOMEDIQ AS

Denmark

EU Contribution

€ 187 470

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Netherlands

EU Contribution

€ 363 643

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 360 000

NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S

Denmark

EU Contribution

€ 648 277

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 336 720

BIOTALENTUM TUDASFEJLESZTO KFT

Hungary

EU Contribution

€ 403 200,77

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 171 230,39

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 386 312

UNIVERSITAETSKLINIKUM AACHEN

Germany

EU Contribution

€ 50 000

THE UNIVERSITY OF NOTTINGHAM

United Kingdom

EU Contribution

€ 726 166,23

EDGELEAP B.V.

Netherlands

EU Contribution

€ 48 656,40

Project information

Grant agreement ID: 305815

Status

Closed project

  • Start date

    1 October 2012

  • End date

    30 September 2017

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 982 003,41

  • EU contribution

    € 5 993 459,09

Coordinated by:

UNIVERSITY OF SURREY

United Kingdom