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Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases

Obiettivo

Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in joint space width (JSW). However, radiographic evidence is seen only after significant cartilage degradation has already taken place. The early stages of the disease may remain latent and asymptomatic for many years. Therefore, there is an acute need for reliable biomarkers and diagnostic tests that can facilitate earlier diagnosis of OA, and inform the prognosis, monitoring and therapeutic strategies for chronic and disabling forms of this disease. However, there is currently a lack of reliable, quantifiable and easily measured biomarkers that provide an earlier diagnosis of OA, inform on the prognostic of the disease and monitor and predict responses to therapeutic modalities. Biomarkers of tissue turnover in joints can reflect disease relevant biological activity and provide valuable information that may be useful diagnostically and therapeutically, potentially enabling a more rational and personalized approach to healthcare management. The proliferation of omic technologies has facilitated rapid progress in biomarker research. Combinations of omic technologies are dominating the biomarker research arena and are playing increasingly important roles in the identification, validation and qualification of new biomarkers. The aim of the D-BOARD consortium is to bring together leading academic institutions and European Small and Medium Enterprises (SMEs) to focus on the identification, validation and qualification of new combination biomarkers and the development of diagnostic tests capable of subclinical disease diagnosis for degenerative and inflammatory diseases of joints.

Campo scientifico

Programma(i)

Argomento(i)

Invito a presentare proposte

FP7-HEALTH-2012-INNOVATION-1
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Meccanismo di finanziamento

CP-FP - Small or medium-scale focused research project

Coordinatore

UNIVERSITY OF SURREY
Contributo UE
€ 879 154,40
Indirizzo
Stag Hill
GU2 7XH Guildford
Regno Unito

Mostra sulla mappa
Regione
South East (England) Surrey, East and West Sussex West Surrey
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Maria Sega-Buhalis (Mrs.)
Collegamenti
Costo totale
Nessun dato

Partecipanti (14)

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Ultimo aggiornamento: 3 Gennaio 2018

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Permalink: https://cordis.europa.eu/project/id/305815/it

European Union, 2024