Objective
Cancer is the second cause of death in Europe, after cardiovascular diseases. These lethal diseases are in desperate need of new therapeutic approaches: despite dramatic advances in the use of conventional chemo and radiotherapy and the growth of more “targeted” drugs, many cancers are still incurable.
Cancers are difficult to treat not because they are so mechanistically diverse (indeed, we argue that cancers are not very diverse mechanistically) but because they evolve in response to any pharmacological elective pressure we impose upon them.
To address this problem, we employ a novel class of genetically engineered mouse (GEM) in which individual tumour suppressor genes may be systemically toggled off and on, reversibly and at will, in vivo. In this way we can identify the most effective therapeutic targets. We hypothesize that targeting the functionally non-degenerate signaling nodes that link robust networks offers two unique advantages as a therapeutic strategy: a durable therapeutic response, and the possibility for treating many distinct cancer types. In this project, we will focus our attention to the non-redundant tumor suppressor p53, and investigate its relevance as a discrete or combined therapeutic target for the treatment of cancer and protection of individuals from radiological or chemotherapeutic injury. Furthermore we will also examine the potential tumour suppressor role of p73, with the same technical approach.
Our overarching aim is to deliver to the pharmaceutical industry pre-clinical models of what drugs would do, both therapeutically and in terms of side effects, were we are able to target any intracellular effector of choice.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.