Objective The doctoral school proposed in DISCo originates from the common interest of Novartis Vaccines (NVD) and the French National Institute of Agronomical Research (INRA) in preventing E. coli infections. Both Institutes have a strong background in microbial pathogenesis, supported by a number of ongoing research programmes aimed at combating human infectious diseases. In particular, NVD, by using a high-throughput in silico genomic approach, named “Reverse Vaccinology”, has recently received approval for the first broad coverage vaccine (Bexsero®) that can help protect all age groups against meningococcal disease. Starting from this successful achievement, we now propose the application of both bioinformatic and experimental approaches (including proteomic, functional and immunological studies) to identify bacterial surface associated determinants able to induce cross-protective antibodies against different E. coli pathotypes. Recently NVD has used a subtractive Reverse Vaccinology approach to identify novel immunogenic antigens capable of inducing protection against extraintestinal pathogenic E. coli species in a mouse model of sepsis. This doctoral program aims to extend such analysis to intestinal E. coli pathotypes for which a broadly protective vaccine would aid in the control of morbidity and mortality associated to diarrheal disease. Therefore, by combining the industrial expertise developed in NVD with the academic research quality of INRA, we propose a strong training programme for young scientists who will have the unique opportunity to learn state-of-the art technologies jointly with the possibility of applying laboratory discoveries to industrial applications. The young fellows’ training path will be complemented by the transferable skills courses, organised by the SME ALTA, and will culminate with the formal obtainment of the PhD title from two well recognized European universities, such as University of Roma 3 (Italy) and University of Auvergne (France). Fields of science social sciencessociologydemographymortalitymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2013-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator GLAXOSMITHKLINE VACCINES SRL EU contribution € 522 109,68 Address VIA FIORENTINA 1 53100 SIENA Italy See on map Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Siciliano Francesco (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France EU contribution € 487 477,32 Address 147 RUE DE L'UNIVERSITE 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Alain Brelurut (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data