Objetivo The impact of weight loss on cardiovascular disease risk within the frame of the Mediterranean dietary pattern has not yet been tested using a sufficiently large randomized trial (Malik, Hu, 2007). We propose to run a parallel group, multi-center, randomized, primary prevention trial (PREDIMED PLUS) on men aged 55-75 years and women 65-75 years, with a body mass index ≥27 to <40 kg/m2 and meeting at least 3 criteria for the metabolic syndrome. The objective of the present research is to address the cardiovascular effect of an intensive weight-loss lifestyle intervention based on an energy-restricted traditional Mediterranean diet in comparison with a less intensive program using Mediterranean diet, but with no energy restriction, behavioural intervention or physical activity programme. The end-point is a composite of major hard clinical cardiovascular events. We hypothesize that an intensive weight-loss lifestyle intervention, including physical activity, based on the traditional Mediterranean food pattern is a sustainable long-term approach for weight reduction among overweight/obese adults and that the achieved lifestyle changes will exert beneficial effects on cardiovascular disease incidence, according to our experience (Estruch R et al., 2012) and research by other investigators (Shai et al., 2008). The rationale for the proposed investigation is that it can provide a new, affordable, and sustainable approach to reduce excess cardiovascular morbidity and mortality among overweight/obese adults, beyond what was already observed in the PREDIMED I trial. Ámbito científico social sciencessociologydemographymortalityengineering and technologymaterials engineeringcompositesmedical and health scienceshealth sciencesnutritionmedical and health sciencesclinical medicinecardiologycardiovascular diseases Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Convocatoria de propuestas ERC-2013-ADG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida UNIVERSIDAD DE NAVARRA Aportación de la UE € 1 496 754,47 Dirección CAMPUS UNIVERSITARIO EDIFICIO CENTRAL 31080 Pamplona España Ver en el mapa Región Noreste Comunidad Foral de Navarra Navarra Tipo de actividad Higher or Secondary Education Establishments Investigador principal Miguel ángel Martínez González (Prof.) Contacto administrativo Fco. Javier Irigoyen Barrio (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSIDAD DE NAVARRA España Aportación de la UE € 1 496 754,47 Dirección CAMPUS UNIVERSITARIO EDIFICIO CENTRAL 31080 Pamplona Ver en el mapa Región Noreste Comunidad Foral de Navarra Navarra Tipo de actividad Higher or Secondary Education Establishments Investigador principal Miguel ángel Martínez González (Prof.) Contacto administrativo Fco. Javier Irigoyen Barrio (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. España Aportación de la UE € 582 215,15 Dirección CALLE MONFORTE DE LEMOS 5 28029 Madrid Ver en el mapa Región Comunidad de Madrid Comunidad de Madrid Madrid Tipo de actividad Research Organisations Contacto administrativo Manuel Sanchez (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
