Objective Graves' orbitopathy (GO), also known as thyroid eye disease, affects approximately 3 million people in Europe with an estimated socioeconomic burden of 6.4 billion euros per annum. GO is a complication of Graves' disease which is an autoimmune disease and the commonest cause of an overactive thyroid gland. The treatment of GO remains unsatisfactory and the majority of patients report long-term impairment of quality of life. To improve the outcomes of people with GO and thus reduce long-term illness and cost to society, research is needed to address the identification of risk factors, develop a better understanding of the pathophysiology of the disease, devise approaches for early diagnosis during the pre-clinical stage of the disease, and create novel and safe interventions. INDIGO will refine and optimise animal and in vitro models of Graves’ disease and GO, which are urgently required to facilitate the study of the pathogenesis of GO. INDIGO will address the identification of risk factors for the initiation and perpetuation of autoimmunity that causes disease, using the latest generation technologies to study variations in the microbiome in Graves and GO patients and controls. The interaction of the gut derived antigens, from micro-organisms and nutrients on the autoimmune response in both the animal model by probiotic and “contra-biotic” intervention. State of the art technology will be used to search for biomarkers that will identify patients that will progress to GO, during the preclinical phase of the disease when intervention is most likely to be successful. The successful completion of the project will be ensured by a partnership involving 2 SMEs, 3 academic institutions and the European Group on Graves' Orbitopathy, each contributing complementary expertise and technology, the project will involve 5 secondments and 3 recruitments that will facilitate the exchange of knowledge and training. Fields of science medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesbasic medicineimmunologyautoimmune diseasesnatural sciencesbiological sciencesmicrobiology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2013-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator CARDIFF UNIVERSITY EU contribution € 295 392,46 Address NEWPORT ROAD 30 36 CF24 0DE Cardiff United Kingdom See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Administrative Contact Keith Sexton (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all PARCO TECNOLOGICO PADANO S.R.L. Italy EU contribution € 239 209,86 Address Via Einstein - Localita Cascina Codazza 26900 LODI See on map Region Nord-Ovest Lombardia Lodi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Simona Palermo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAETSKLINIKUM ESSEN Germany EU contribution € 108 113,28 Address HUFELANDSTRASSE 55 45147 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Sebastian George (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CULTECH LTD United Kingdom EU contribution € 234 886,74 Address CHRISTCHURCH ROAD UNIT 2 SA12 7BZ PORT TALBOT WEST GLAMORGAN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Susan Plummer (Dr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI MILANO Italy EU contribution € 315 196,20 Address Via Festa Del Perdono 7 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Anna Spada (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
