Objective Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer.The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develop and the prognosis of that particular subtype. This will be accomplished through large-scale pathologic-molecular analyses of over 20,000 breast tumours, and the integration of these data with unique resources from existing consortia, including germline, lifestyle/environmental, mammographic breast density, pathologic and clinical data. This information will inform the development of risk prediction and prognostication models that will be validated in longitudinal cohorts and clinical studies, and incorporated into online tools. We will also disseminate this knowledge to relevant stakeholders, and evaluate how to translate it into risk-stratified public health and clinical strategies.The current challenge for optimised prevention, early detection, and treatment decisions for breast cancer is understanding the genetic and lifestyle determinants of risk and prognosis of molecular subtypes. B-CAST will add to this understanding and will have immediate application with benefits to women by providing validated risk and prognostication tools. This will empower women and doctors with knowledge to tailor strategies for prevention and treatment. Ultimately, this work should result in reductions in the occurrence, morbidity and mortality of this disease. Fields of science medical and health scienceshealth sciencespublic healthsocial sciencessociologydemographymortalitynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesbiological sciencesgeneticsRNA Keywords breast cancer risk stratification prognostication molecular subtypes lifestyle breast density germline susceptibility variants tumour sequencing Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) PHC-01-2014 - Understanding health, ageing and disease: determinants, risk factors and pathways Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2014-two-stage Funding Scheme RIA - Research and Innovation action Coordinator STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Net EU contribution € 925 687,50 Address PLESMANLAAN 121 1066 CX Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 925 687,50 Participants (12) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG United Kingdom Net EU contribution € 383 306,25 Address OLD BROMPTON ROAD 123 SW7 3RP London See on map Region London Inner London — West Kensington & Chelsea and Hammersmith & Fulham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 383 306,25 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 1 056 118,75 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 056 118,75 KAROLINSKA INSTITUTET Sweden Net EU contribution € 350 000,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 350 000,00 DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany Net EU contribution € 268 750,00 Address IM NEUENHEIMER FELD 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 268 750,00 UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Spain Net EU contribution € 399 000,00 Address COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N 15782 Santiago De Compostela See on map Region Noroeste Galicia A Coruña Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 399 000,00 FUNDACIO PARC CIENTIFIC DE BARCELONA Participation ended Spain Net EU contribution € 0,00 Address BALDIRI I REIXAC 4 08028 Barcelona See on map Region Este Cataluña Barcelona Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data VIB VZW Belgium Net EU contribution € 63 750,00 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 63 750,00 FOUNDATION FOR GENOMICS & POPULATION HEALTH United Kingdom Net EU contribution € 228 618,75 Address WORTS CAUSEWAY 2 CB1 8RN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 228 618,75 UNIVERSITE LAVAL Canada Net EU contribution € 0,00 Address ALLEE DES BIBLIOTHEQUES 2345 G1V 0A6 Quebec See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 37 500,00 QUEENSLAND INSTITUTE OF MEDICAL RESEARCH Australia Net EU contribution € 0,00 Address Herston Road, 300 QLD 4006 Herston See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 37 500,00 HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. United States Net EU contribution € 0,00 Address OFFICE OF THE GENERAL COUNSEL, HOLYOKE CENTER, SUITE 980, MASSACHUSETTS AVENUE 1350 02138 Cambridge See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 62 500,00 FUNDACIO CENTRE DE REGULACIO GENOMICA Spain Net EU contribution € 2 308 125,00 Address CARRER DOCTOR AIGUADER 88 08003 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 308 125,00