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Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes

Deliverables

D8.2 Report of International Force Field analysis workshop and identification of key areas for strategy development

Report of International Force Field analysis workshop and identification of key areas for strategy development

D1.5 End-term meeting together with BRIDGES

Endterm meeting together with BRIDGESDelay due to COVID19 Due date to be moved to M66 BCAST planned deliverable D15 together with BRIDGES from 26th29th June 2020 in Leiden which has been cancelled due to the COVID19 crisis The purpose of the meeting was to disseminate the results of both BCAST and BRIDGES to the wider scientific community as the two consortia have worked synergistically for the last 5 years As the possibility of holding a physical meeting by Feb 2021 still appears slim we hope to get a further 6 month extension to be able to organise the meeting at a later point next year

D4.2 Description of database for mammographic density

Description of database for mammographic density

D3.1 List of genes in panel for targeted DNA sequencing

List of genes in panel for targeted DNA sequencing

D4.1 Description of database for environmental risk factors

Description of database for environmental risk factors

D1.2 Final report on successfully performed communication, dissemination, exploitation activities.

Final report on successfully performed communication dissemination exploitation activitiesDelay due to COVID19 due date to be moved to M66 We were making steady progress with milestones and deliverables from WP2 MS 23 MS 24 D23 and WP3 MS 3235 D32 which were delayed previously as reported in RP2 also indicated in this table below Due to the sudden reduction in lab capacities as the COVID19 crisis evolved some parts of the final analyses on the TMAs for WP2 D23 and about 1000 samples still remain to be sequenced at CNAG MS34 consequently on MS35 and D32 which was otherwise expected to be completed by midApril 2020 With the requested extension we will be able to complete our target of generating new genomic information based on IHCISH panels on 25873 tumours and targeted sequencing on a subset of 10000 tumours that will inform risk and prognosis modelling of breast cancer Additionally we can then include these analyses in our manuscripts which will play a key role in informing the scientific community about our results

D4.3 Description of genotyping database

Description of genotyping database

D8.1 Report on current public health and policy discourses on personalised breast cancer prevention

Report on current public health and policy discourses on personalised breast cancer prevention

D8.3 Final report on personalised breast cancer prevention aimed at public health professionals and policy makers

Final report on personalised breast cancer prevention aimed at public health professionals and policy makers

D7.1 Web-tool (in English) that predicts overall breast cancer risk and the risks for breast cancer subtypes

Webtool in English that predicts overall breast cancer risk and the risks for breast cancer subtypes

D1.1. Website for internal and external communication

Website for internal and external communication Note dissemination level: some parts of the website will only be for project members (CO)

D7.3 Translated versions of the risk prediction and prognosis tools in other languages

Translated versions of the risk prediction and prognosis tools in other languages

D7.2 Web-tool (in English) that predicts survival after a breast cancer diagnosis

Webtool in English that predicts survival after a breast cancer diagnosis

Publications

Identification of Women at High Risk of Breast Cancer Who Need Supplemental Screening

Author(s): Mikael Eriksson, Kamila Czene, Fredrik Strand, Sophia Zackrisson, Peter Lindholm, Kristina Lång, Daniel Förnvik, Hanna Sartor, Nasim Mavaddat, Doug Easton, Per Hall
Published in: Radiology, 297/2, 2020, Page(s) 327-333, ISSN 0033-8419
Publisher: Radiological Society of North America
DOI: 10.1148/radiol.2020201620

Predictors of mammographic microcalcifications

Author(s): Shadi Azam, Mikael Eriksson, Arvid Sjölander, Marike Gabrielson, Roxanna Hellgren, Kamila Czene, Per Hall
Published in: International Journal of Cancer, 148/5, 2021, Page(s) 1132-1143, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33302

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Author(s): Nichola Johnson, Sarah Maguire, Anna Morra, Pooja Middha Kapoor, Katarzyna Tomczyk, Michael E. Jones, Minouk J. Schoemaker, Clare Gilham, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Caroline Baynes, Laura E. Beane Freeman, Matthias W. Beckmann, Javier Benitez, Marina
Published in: British Journal of Cancer, 124/4, 2021, Page(s) 842-854, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-020-01185-w

Comparative validation of the BOADICEA and Tyrer-Cuzick breast cancer risk models incorporating classical risk factors and polygenic risk in a population-based prospective cohort of women of European ancestry

Author(s): Parichoy Pal Choudhury, Mark N. Brook, Amber N. Hurson, Andrew Lee, Charlotta V. Mulder, Penny Coulson, Minouk J. Schoemaker, Michael E. Jones, Anthony J. Swerdlow, Nilanjan Chatterjee, Antonis C. Antoniou, Montserrat Garcia-Closas
Published in: Breast Cancer Research, 23/1, 2021, ISSN 1465-542X
Publisher: BMC Springer Nature
DOI: 10.1186/s13058-021-01399-7

Personalized early detection and prevention of breast cancer: ENVISION consensus statement

Author(s): Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, Davi
Published in: Nature Reviews Clinical Oncology, 17/11, 2020, Page(s) 687-705, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-020-0388-9

CanRisk Tool—A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants

Author(s): Tim Carver, Simon Hartley, Andrew Lee, Alex P. Cunningham, Stephanie Archer, Chantal Babb de Villiers, Jonathan Roberts, Rod Ruston, Fiona M. Walter, Marc Tischkowitz, Douglas F. Easton, Antonis C. Antoniou
Published in: Cancer Epidemiology Biomarkers & Prevention, 30/3, 2021, Page(s) 469-473, ISSN 1055-9965
Publisher: American Association for Cancer Research
DOI: 10.1158/1055-9965.epi-20-1319

Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk

Author(s): Pooja Middha Kapoor, Nasim Mavaddat, Parichoy Pal Choudhury, Amber N Wilcox, Sara Lindström, Sabine Behrens, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Qin Wang, Audrey Jung, Zomoroda Abu-Ful, Thomas Ahearn, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Lesl
Published in: JNCI: Journal of the National Cancer Institute, 113/3, 2020, Page(s) 329-337, ISSN 0027-8874
Publisher: Oxford University Press
DOI: 10.1093/jnci/djaa056

Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries

Author(s): Amber N Hurson, Parichoy Pal Choudhury, Chi Gao, Anika Hüsing, Mikael Eriksson, Min Shi, Michael E Jones, D Gareth R Evans, Roger L Milne, Mia M Gaudet, Celine M Vachon, Daniel I Chasman, Douglas F Easton, Marjanka K Schmidt, Peter Kraft, Montserrat Garcia-Closas, Nilanjan Chatterjee, Christopher G Scott, Brian D Carter, Kara Martin, Elaine F Harkness, Mark N Brook, Thomas U Ahearn, Nasim Mavadda
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyab036

Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women

Author(s): Leila Dorling, Sara Carvalho, Jamie Allen, Anna González-Neira, Craig Luccarini, Cecilia Wahlström, Karen A. Pooley, Michael T. Parsons, Cristina Fortuno, Qin Wang, Manjeet K. Bolla, Joe Dennis, Renske Keeman, M. Rosario Alonso, Nuria Álvarez, Belen Herraez, Victoria Fernandez, Rocio Núñez-Torres, Ana Osorio, Jeanette Valcich, Minerva Li, Therese Törngren, Patricia A. Harrington, Caroline Ba
Published in: New England Journal of Medicine, 384/5, 2021, Page(s) 428-439, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmoa1913948

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Author(s): Iris Kramer, Maartje J. Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W. Steyerberg, Daniele Giardiello, Antonis C. Antoniou, Paul D.P. Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L. Andrulis, Hoda Anton-Culver, Kristan J. Aronson, Annelie Augustinsson, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V. Bogdanova, Stig E. Boje
Published in: The American Journal of Human Genetics, 107/5, 2020, Page(s) 837-848, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2020.09.001

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

Author(s): Myrto Barrdahl, Anja Rudolph, John L. Hopper, Melissa C. Southey, Annegien Broeks, Peter A. Fasching, Matthias W. Beckmann, Manuela Gago-Dominguez, J. Esteban Castelao, Pascal Guénel, Thérèse Truong, Stig E. Bojesen, Susan M. Gapstur, Mia M. Gaudet, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Ute Hamann, Arto Mannermaa, Diether Lambrechts, Lynn Jongen, Dieter Flesch-Janys, Kathrin Thoene, Fe
Published in: International Journal of Cancer, 141/9, 2017, Page(s) 1830-1840, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.30859

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

Author(s): Anja Rudolph, Minsun Song, Mark N Brook, Roger L Milne, Nasim Mavaddat, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Amber N Wilcox, John L Hopper, Melissa C Southey, Renske Keeman, Peter A Fasching, Matthias W Beckmann, Manuela Gago-Dominguez, Jose E Castelao, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Henrik Flyger, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Thomas Brü
Published in: International Journal of Epidemiology, 47/2, 2018, Page(s) 526-536, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyx242

A comprehensive tool for measuring mammographic density changes over time

Author(s): Mikael Eriksson, Jingmei Li, Karin Leifland, Kamila Czene, Per Hall
Published in: Breast Cancer Research and Treatment, 169/2, 2018, Page(s) 371-379, ISSN 0167-6806
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10549-018-4690-5

Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries

Author(s): Anne Brédart, Jean-Luc Kop, Antonis C. Antoniou, Alex P. Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Sylvie Dolbeault, Léonore Robieux, Kerstin Rhiem, Douglas F. Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Published in: Familial Cancer, 17/1, 2018, Page(s) 31-41, ISSN 1389-9600
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10689-017-0014-x

A clinical model for identifying the short-term risk of breast cancer

Author(s): Mikael Eriksson, Kamila Czene, Yudi Pawitan, Karin Leifland, Hatef Darabi, Per Hall
Published in: Breast Cancer Research, 19/1, 2017, ISSN 1465-542X
Publisher: BMC
DOI: 10.1186/s13058-017-0820-y

Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer: A multi-methods study

Author(s): Stephanie Archer, Chantal Babb de Villiers, Fiona Scheibl, Tim Carver, Simon Hartley, Andrew Lee, Alex P. Cunningham, Douglas F. Easton, Jennifer G. McIntosh, Jon Emery, Marc Tischkowitz, Antonis C. Antoniou, Fiona M. Walter
Published in: PLOS ONE, 15/3, 2020, Page(s) e0229999, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0229999

Transcriptome‐wide association study of breast cancer risk by estrogen‐receptor status

Author(s): Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu‐full, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Antonis C. Antoniou, Adalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Paul L. Auer, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens,
Published in: Genetic Epidemiology, 2020, ISSN 0741-0395
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/gepi.22288

Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium

Author(s): Pooja Middha Kapoor, Sara Lindström, Sabine Behrens, Xiaoliang Wang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Alison M Dunning, Paul D P Pharoah, Marjanka K Schmidt, Peter Kraft, Montserrat García-Closas, Douglas F Easton, Roger L Milne, Jenny Chang-Claude
Published in: International Journal of Epidemiology, 49/1, 2019, Page(s) 216-232, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyz193

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

Author(s): Maria Escala-Garcia, Jean Abraham, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Alan Ashworth, Paul L. Auer, Päivi Auvinen, Matthias W. Beckmann, Jonathan Beesley, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, William Blot, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne-Lise Børresen-Dale, Hiltrud Brauch, Hermann Brenner, Sara Y. Brucker, Barbara Burwin
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-14100-6

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Author(s): Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R. Barnes, Jamie Allen, Siddhartha Kar, Karen A. Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemaçon, Michael Lush, Jonathan P. Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomäki, M. Rosario Alonso, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Adalge
Published in: Nature Genetics, 52/1, 2020, Page(s) 56-73, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0537-1

Prediction and clinical utility of a contralateral breast cancer risk model

Author(s): Daniele Giardiello, Ewout W. Steyerberg, Michael Hauptmann, Muriel A. Adank, Delal Akdeniz, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Mariël Brinkhuis, Jenny Chang-Claude, Kamila Czene, Peter Devilee, Alison M. Dunning, Douglas F. Easton, Diana M. Eccles, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Ha
Published in: Breast Cancer Research, 21/1, 2019, ISSN 1465-542X
Publisher: BMC
DOI: 10.1186/s13058-019-1221-1

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Author(s): Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna I. Kiiski, Taru A. Muranen, Daniel R. Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K. Bolla, Goska Leslie, Cora M. Aalfs, Muriel A. Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A. Agnarsson, Thomas Ahearn, Kristiina Aittomäki, Christine B. Ambrosone, Lesley Andrews, Hoda Anton
Published in: npj Breast Cancer, 5/1, 2019, ISSN 2374-4677
Publisher: Nature Partner Journal Series
DOI: 10.1038/s41523-019-0127-5

Two truncating variants in FANCC and breast cancer risk

Author(s): Thilo Dörk, Paolo Peterlongo, Arto Mannermaa, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Laura E. Beane Freeman, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia V. Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Barbara Burw
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-48804-y

The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium

Author(s): Tomotaka Ugai, Roger L. Milne, Hidemi Ito, Kristan J. Aronson, Manjeet K. Bolla, Tsun Chan, Ching W. Chan, Ji-Yeob Choi, Don M. Conroy, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Valerie Gaborieau, Anna Gonzalez-Neira, Mikael Hartman, Catherine S. Healey, Motoki Iwasaki, Esther M. John, Daehee Kang, Sung-Won Kim, Ava Kwong, Artitaya Lophatananon, Kyriaki Michailidou, Nur Aishah Mohd Taib, K
Published in: Molecular Genetics & Genomic Medicine, 7/6, 2019, Page(s) e707, ISSN 2324-9269
Publisher: Wiley
DOI: 10.1002/mgg3.707

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Author(s): Celine M. Vachon, Christopher G. Scott, Rulla M. Tamimi, Deborah J. Thompson, Peter A. Fasching, Jennifer Stone, Melissa C. Southey, Stacey Winham, Sara Lindström, Jenna Lilyquist, Graham G. Giles, Roger L. Milne, Robert J. MacInnis, Laura Baglietto, Jingmei Li, Kamila Czene, Manjeet K. Bolla, Qin Wang, Joe Dennis, Lothar Haeberle, Mikael Eriksson, Peter Kraft, Robert Luben, Nick Wareham, Janet E
Published in: Breast Cancer Research, 21/1, 2019, ISSN 1465-542X
Publisher: BMC part of Springer Nature
DOI: 10.1186/s13058-019-1138-8

Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228 951 Women of European Descent

Author(s): Yaohua Yang, Lang Wu, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Xingyi Guo, Fei Ye, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Irene L Andrulis, Hermann Brenner, Georgia Chenevix-Trench, Daniele Campa, Jose E Castelao, Manuela Gago-Dominguez, Thilo Dörk, Antoinette Hollestelle, Artitaya Lophatananon, Kenneth Muir, Susan L Neuhausen, Håkan Olsson, Dale P Sandler, Jacques S
Published in: JNCI: Journal of the National Cancer Institute, 112/3, 2019, Page(s) 295-304, ISSN 0027-8874
Publisher: Oxford University Press
DOI: 10.1093/jnci/djz109

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Author(s): Manuel A. Ferreira, Eric R. Gamazon, Fares Al-Ejeh, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Adalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Jacopo Azzollini, Judith Balmaña, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Białkowska, Carl Blomqvist, Natalia V. Bogdanova,
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-08053-5

Genome-wide association study of germline variants and breast cancer-specific mortality

Author(s): Maria Escala-Garcia, Qi Guo, Thilo Dörk, Sander Canisius, Renske Keeman, Joe Dennis, Jonathan Beesley, Julie Lecarpentier, Manjeet K. Bolla, Qin Wang, Jean Abraham, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Paul L. Auer, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Bram Boeckx, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Bø
Published in: British Journal of Cancer, 120/6, 2019, Page(s) 647-657, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-019-0393-x

Shared heritability and functional enrichment across six solid cancers

Author(s): Xia Jiang, Hilary K. Finucane, Fredrick R. Schumacher, Stephanie L. Schmit, Jonathan P. Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B. Kuchenbaecker, Joe Dennis, David V. Conti, Graham Casey, Mia M. Gaudet, Jeroen R. Huyghe, Demetrius Albanes, Melinda C. Aldrich, Angeline S. Andrew, Irene L. Andrulis, Hoda Anton-Culver, Antonis C. Antoniou, Natalia N. Antonenkova, Susanne M.
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-08054-4

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

Author(s): Andrew Lee, Nasim Mavaddat, Amber N. Wilcox, Alex P. Cunningham, Tim Carver, Simon Hartley, Chantal Babb de Villiers, Angel Izquierdo, Jacques Simard, Marjanka K. Schmidt, Fiona M. Walter, Nilanjan Chatterjee, Montserrat Garcia-Closas, Marc Tischkowitz, Paul Pharoah, Douglas F. Easton, Antonis C. Antoniou
Published in: Genetics in Medicine, 21/8, 2019, Page(s) 1708-1718, ISSN 1098-3600
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41436-018-0406-9

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Author(s): Nasim Mavaddat, Kyriaki Michailidou, Joe Dennis, Michael Lush, Laura Fachal, Andrew Lee, Jonathan P. Tyrer, Ting-Huei Chen, Qin Wang, Manjeet K. Bolla, Xin Yang, Muriel A. Adank, Thomas Ahearn, Kristiina Aittomäki, Jamie Allen, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Päivi Auvinen, Myrto Barrdahl, Laura E. Beane Freeman, Matth
Published in: The American Journal of Human Genetics, 104/1, 2019, Page(s) 21-34, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2018.11.002

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Author(s): Lang Wu, Wei Shi, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Jonathan Beesley, Manjeet K. Bolla, Xiao-Ou Shu, Yingchang Lu, Qiuyin Cai, Fares Al-Ejeh, Esdy Rozali, Qin Wang, Joe Dennis, Bingshan Li, Chenjie Zeng, Helian Feng, Alexander Gusev, Richard T. Barfield, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Myrto Barrdahl, Caroline Baynes, Matthias W. Be
Published in: Nature Genetics, 50/7, 2018, Page(s) 968-978, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0132-x

E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Author(s): Hisani N. Horne, Hannah Oh, Mark E. Sherman, Maya Palakal, Stephen M. Hewitt, Marjanka K. Schmidt, Roger L. Milne, David Hardisson, Javier Benitez, Carl Blomqvist, Manjeet K. Bolla, Hermann Brenner, Jenny Chang-Claude, Renata Cora, Fergus J. Couch, Katarina Cuk, Peter Devilee, Douglas F. Easton, Diana M. Eccles, Ursula Eilber, Jaana M. Hartikainen, Päivi Heikkilä, Bernd Holleczek, Maartje J. Hoo
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-23733-4

Clinicians’ use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors: an international survey

Author(s): Anne Brédart, Jean-Luc Kop, Antonis C. Antoniou, Alex P. Cunningham, Antoine De Pauw, Marc Tischkowitz, Hans Ehrencrona, Marjanka K. Schmidt, Sylvie Dolbeault, Kerstin Rhiem, Douglas F. Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Published in: Journal of Community Genetics, 10/1, 2019, Page(s) 61-71, ISSN 1868-310X
Publisher: Springer Verlag
DOI: 10.1007/s12687-018-0362-8

Association analysis identifies 65 new breast cancer risk loci

Author(s): Kyriaki Michailidou, Sara Lindström, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey Lemaçon, Penny Soucy, Dylan Glubb, Asha Rostamianfar, Manjeet K. Bolla, Qin Wang, Jonathan Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D. French, Xiao Qing Chen, Laura Fachal, Karen McCue, Amy E. McCart Reed, Maya Ghoussaini, Jason S. Carroll, X
Published in: Nature, 551/7678, 2017, Page(s) 92-94, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature24284

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Author(s): Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindström, Shirley Hui, Audrey Lemaçon, Penny Soucy, Joe Dennis, Xia Jiang, Asha Rostamianfar, Hilary Finucane, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Cora M Aalfs, Marcia Adams, Julian Adlard, Simona Agata, Shahana Ahmed, Habibul Ahsan, Kristiina Aittomäki, Fares Al-Ejeh, Jamie Allen, Chri
Published in: Nature Genetics, 49/12, 2017, Page(s) 1767-1778, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3785

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Author(s): Felix R Day, Deborah J Thompson, Hannes Helgason, Daniel I Chasman, Hilary Finucane, Patrick Sulem, Katherine S Ruth, Sean Whalen, Abhishek K Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M Barbieri, Thibaud Boutin, Archie Campbell, Ellen Demerath, Ayush Giri, Chunyan He, Jouke J Hottenga, Robert Karlsson, Ivana Kolcic, Po-Ru Loh, Kathryn L Lunetta, Massimo Mangino, Brumat Marc
Published in: Nature Genetics, 49/6, 2017, Page(s) 834-841, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3841

pedigreejs: a web-based graphical pedigree editor

Author(s): Tim Carver, Alex P Cunningham, Chantal Babb de Villiers, Andrew Lee, Simon Hartley, Marc Tischkowitz, Fiona M Walter, Douglas F Easton, Antonis C Antoniou
Published in: Bioinformatics, 34/6, 2017, Page(s) 1069-1071, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btx705

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

Author(s): Xiang Jiao, Christos Aravidis, Rajeshwari Marikkannu, Johanna Rantala, Simone Picelli, Tatjana Adamovic, Tao Liu, Paula Maguire, Barbara Kremeyer, Liping Luo, Susanna von Holst, Vinaykumar Kontham, Jessada Thutkawkorapin, Sara Margolin, Quan Du, Johanna Lundin, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton-Culver, N
Published in: Oncotarget, 8/61, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.21800

Physical activity and mammographic density in an Asian multi-ethnic cohort

Author(s): Wee Heng Soh, Nadia Rajaram, Shivaani Mariapun, Mikael Eriksson, Farhana Fadzli, Weang Kee Ho, Nur Aishah Mohd Taib, Per Hall, Soo-Hwang Teo
Published in: Cancer Causes & Control, 29/9, 2018, Page(s) 883-894, ISSN 0957-5243
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10552-018-1064-6

Mammographic Density Change and Risk of Breast Cancer

Author(s): Shadi Azam, Mikael Eriksson, Arvid Sjölander, Roxanna Hellgren, Marike Gabrielson, Kamila Czene, Per Hall
Published in: JNCI: Journal of the National Cancer Institute, 112/4, 2019, Page(s) 391-399, ISSN 0027-8874
Publisher: Oxford University Press
DOI: 10.1093/jnci/djz149

Determinants of Mammographic Density Change

Author(s): Shadi Azam, Arvid Sjölander, Mikael Eriksson, Marike Gabrielson, Kamila Czene, Per Hall
Published in: JNCI Cancer Spectrum, 3/1, 2019, ISSN 2515-5091
Publisher: Oxford University Press
DOI: 10.1093/jncics/pkz004

Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study

Author(s): Signe Borgquist, Ann H. Rosendahl, Kamila Czene, Nirmala Bhoo-Pathy, Mozhgan Dorkhan, Per Hall, Judith S. Brand
Published in: Breast Cancer Research, 20/1, 2018, ISSN 1465-542X
Publisher: BMC part of Springer Nature
DOI: 10.1186/s13058-018-1026-7

Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

Author(s): Xiang Shu, Lang Wu, Nikhil K Khankari, Xiao-Ou Shu, Thomas J Wang, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Roger L Milne, Marjanka K Schmidt, Paul D P Pharoah, Irene L Andrulis, David J Hunter, Jacques Simard, Douglas F Easton, Wei Zheng, Beeghly-Fadiel J Alicia, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Paul L Auer, Myrto Barrdahl, Caroline Bay
Published in: International Journal of Epidemiology, 48/3, 2018, Page(s) 795-806, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyy201

Common genetic variation and novel loci associated with volumetric mammographic density

Author(s): Judith S. Brand, Keith Humphreys, Jingmei Li, Robert Karlsson, Per Hall, Kamila Czene
Published in: Breast Cancer Research, 20/1, 2018, ISSN 1465-542X
Publisher: BMC part of Springer Nature
DOI: 10.1186/s13058-018-0954-6

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

Author(s): Michael T. Parsons, Emma Tudini, Hongyan Li, Eric Hahnen, Barbara Wappenschmidt, Lidia Feliubadaló, Cora M. Aalfs, Simona Agata, Kristiina Aittomäki, Elisa Alducci, María Concepción Alonso‐Cerezo, Norbert Arnold, Bernd Auber, Rachel Austin, Jacopo Azzollini, Judith Balmaña, Elena Barbieri, Claus R. Bartram, Ana Blanco, Britta Blümcke, Sandra Bonache, Bernardo Bonanni, Åke Borg, Beatrice B
Published in: Human Mutation, 40/9, 2019, Page(s) 1557-1578, ISSN 1059-7794
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/humu.23818

Personalised early detection and prevention of breast cancer: ENVISION Network Consensus Statement 

Author(s): Nora Pashayan, Antonis Antoniou, Urska Ivanus, Laura Esserman, Douglas Easton, David French French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montse Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Rossi, Jelle Wesseling, David Ritchie, Ma
Published in: Nature Reviews Clinical Oncology, 2020, ISSN 1759-4774
Publisher: Nature Publishing Group

Combined associations of a polygenic risk score and classical risk factors with breast cancer risk

Author(s): Kapoor et al
Published in: JNCI, 2020, ISSN 0027-8874
Publisher: Oxford University Press

Genetic predisposition to mosaic Y chromosome loss in blood

Author(s): Deborah J. Thompson, Giulio Genovese, Jonatan Halvardson, Jacob C. Ulirsch, Daniel J. Wright, Chikashi Terao, Olafur B. Davidsson, Felix R. Day, Patrick Sulem, Yunxuan Jiang, Marcus Danielsson, Hanna Davies, Joe Dennis, Malcolm G. Dunlop, Douglas F. Easton, Victoria A. Fisher, Florian Zink, Richard S. Houlston, Martin Ingelsson, Siddhartha Kar, Nicola D. Kerrison, Ben Kinnersley, Ragnar P. Kristja
Published in: Nature, 575/7784, 2019, Page(s) 652-657, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1765-3

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

Author(s): Jingjing Liu, Wendy J. C. Prager - van der Smissen, J. Margriet Collée, Manjeet K. Bolla, Qin Wang, Kyriaki Michailidou, Joe Dennis, Thomas U. Ahearn, Kristiina Aittomäki, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Annelie Augustinsson, Päivi Auvinen, Heiko Becher, Matthias W. Beckmann, Sabine Behre
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65665-y

Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium

Author(s): Anna Morra, Audrey Y. Jung, Sabine Behrens, Renske Keeman, Thomas U. Ahearn, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Päivi K. Auvinen, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Ignacio Briceno, Sara Y. Brucker, Nicola J. Camp, Daniele Campa, Federico Canzian, Jose E. Castelao, Stephen J. Chanock,
Published in: Cancer Epidemiology Biomarkers & Prevention, 30/4, 2021, Page(s) 623-642, ISSN 1055-9965
Publisher: American Association for Cancer Research
DOI: 10.1158/1055-9965.epi-20-0924

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Author(s): Haoyu Zhang, Thomas U. Ahearn, Julie Lecarpentier, Daniel Barnes, Jonathan Beesley, Guanghao Qi, Xia Jiang, Tracy A. O’Mara, Ni Zhao, Manjeet K. Bolla, Alison M. Dunning, Joe Dennis, Qin Wang, Zumuruda Abu Ful, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Paul L. Auer, Jacopo Azzollini, Daniel Barrowdale, Heiko Becher, Matthias W. Be
Published in: Nature Genetics, 52/6, 2020, Page(s) 572-581, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-0609-2

Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts

Author(s): Daniele Giardiello, Michael Hauptmann, Ewout W. Steyerberg, Muriel A. Adank, Delal Akdeniz, Jannet C. Blom, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Mariël Brinkhuis, Jenny Chang-Claude, Kamila Czene, Peter Devilee, Alison M. Dunning, Douglas F. Easton, Diana M. Eccles, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Lothar Haeberle, Christopher A. Haiman,
Published in: Breast Cancer Research and Treatment, 181/2, 2020, Page(s) 423-434, ISSN 0167-6806
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10549-020-05611-8

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Author(s): Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A. O’Mara, Joe Dennis, Jonathan P. Tyrer, Daniel R. Barnes, Lesley McGuffog, Goska Leslie, Manjeet K. Bolla, Muriel A. Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Banu K. Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Car
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20496-3

Personalised prevention in breast cancer - the policy landscape

Author(s): Sowmiya Moorthie, Louise Gaynor, Hilary Burton, Alison Hall, Mark Kroese, Sobia Raza
Published in: 2017, ISBN 978-1-907198-29-8
Publisher: PHG Foundation, Cambridge

Personalising breast cancer prevention – bridging the gap between research and policy

Author(s): Sowmiya Moorthie, Hilary Burton and Chantal Babb de Villiers
Published in: 2020
Publisher: PHG Foundation Cambridge, UK

Personalising prevention for breast cancer - a workhop report

Author(s): Sowmiya Moorthie, Hilary Burton, Louise Gaynor, Tanya Brigden, Chantal Babb de Villiers
Published in: 2019
Publisher: PHG foundation Cambridge