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Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes

Objective

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer.
The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develop and the prognosis of that particular subtype. This will be accomplished through large-scale pathologic-molecular analyses of over 20,000 breast tumours, and the integration of these data with unique resources from existing consortia, including germline, lifestyle/environmental, mammographic breast density, pathologic and clinical data. This information will inform the development of risk prediction and prognostication models that will be validated in longitudinal cohorts and clinical studies, and incorporated into online tools. We will also disseminate this knowledge to relevant stakeholders, and evaluate how to translate it into risk-stratified public health and clinical strategies.
The current challenge for optimised prevention, early detection, and treatment decisions for breast cancer is understanding the genetic and lifestyle determinants of risk and prognosis of molecular subtypes. B-CAST will add to this understanding and will have immediate application with benefits to women by providing validated risk and prognostication tools. This will empower women and doctors with knowledge to tailor strategies for prevention and treatment. Ultimately, this work should result in reductions in the occurrence, morbidity and mortality of this disease.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Address
Plesmanlaan 121
1066 CX Amsterdam
Netherlands
Activity type
Research Organisations
EU contribution
€ 925 687,50

Participants (12)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
EU contribution
€ 383 306,25
Address
Old Brompton Road 123
SW7 3RP London
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 1 056 118,75
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 350 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 268 750
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
EU contribution
€ 399 000
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Activity type
Higher or Secondary Education Establishments
FUNDACIO PARC CIENTIFIC DE BARCELONA

Participation ended

Spain
EU contribution
€ 0
Address
Baldiri I Reixac 4
08028 Barcelona
Activity type
Research Organisations
VIB VZW
Belgium
EU contribution
€ 63 750
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
FOUNDATION FOR GENOMICS & POPULATION HEALTH
United Kingdom
EU contribution
€ 228 618,75
Address
Worts Causeway 2
CB1 8RN Cambridge
Activity type
Research Organisations
UNIVERSITE LAVAL
Canada
EU contribution
€ 0
Address
Allee Des Bibliotheques 2345
G1V 0A6 Quebec
Activity type
Higher or Secondary Education Establishments
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
EU contribution
€ 0
Address
Herston Road, 300
QLD 4006 Herston
Activity type
Research Organisations
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
United States
EU contribution
€ 0
Address
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge
Activity type
Research Organisations
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 2 308 125
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations