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Alzheimer's disease and Zinc: the missing link ?

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Publications

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

Author(s): Clémence Cheignon, Megan Jones, Elena Atrián-Blasco, Isabelle Kieffer, Peter Faller, Fabrice Collin, Christelle Hureau
Published in: Chem. Sci., Issue 8/7, 2017, Page(s) 5107-5118, ISSN 2041-6520
DOI: 10.1039/C7SC00809K

Link between Affinity and Cu(II) Binding Sites to Amyloid-β Peptides Evaluated by a New Water-Soluble UV–Visible Ratiometric Dye with a Moderate Cu(II) Affinity

Author(s): Amandine Conte-Daban, Valentina Borghesani, Stéphanie Sayen, Emmanuel Guillon, Yves Journaux, Geoffrey Gontard, Laurent Lisnard, Christelle Hureau
Published in: Analytical Chemistry, Issue 89/3, 2017, Page(s) 2155-2162, ISSN 0003-2700
DOI: 10.1021/acs.analchem.6b04979

A Trishistidine Pseudopeptide with Ability to Remove Both Cu Ι and Cu ΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation

Author(s): Amandine Conte-Daban, Bastien Boff, Andreza Candido Matias, Claudia N. Montes Aparicio, Christelle Gateau, Colette Lebrun, Giselle Cerchiaro, Isabelle Kieffer, Stéphanie Sayen, Emmanuel Guillon, Pascale Delangle, Christelle Hureau
Published in: Chemistry - A European Journal, 2017, ISSN 0947-6539
DOI: 10.1002/chem.201703429

Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteins

Author(s): Elena Atrián-Blasco, Alice Santoro, Dean L. Pountney, Gabriele Meloni, Christelle Hureau, Peter Faller
Published in: Chemical Society Reviews, 2017, ISSN 0306-0012
DOI: 10.1039/C7CS00448F

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Author(s): C. Cheignon, M. Tomas, D. Bonnefont-Rousselot, P. Faller, C. Hureau, F. Collin
Published in: Redox Biology, Issue 14, 2018, Page(s) 450-464, ISSN 2213-2317
DOI: 10.1016/j.redox.2017.10.014

Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level

Author(s): Elena Atrián-Blasco, Amandine Conte-Daban, Christelle Hureau
Published in: Dalton Trans., Issue 46/38, 2017, Page(s) 12750-12759, ISSN 1477-9226
DOI: 10.1039/C7DT01344B

Cu II Binding to Various Forms of Amyloid-β Peptides: Are They Friends or Foes?

Author(s): Valentina Borghesani, Bruno Alies, Christelle Hureau
Published in: European Journal of Inorganic Chemistry, 2017, ISSN 1434-1948
DOI: 10.1002/ejic.201700776

N 4 -Tetradentate Chelators Efficiently Regulate Copper Homeostasis and Prevent ROS Production Induced by Copper-Amyloid-β 1-16

Author(s): Weixin Zhang, Yan Liu, Christelle Hureau, Anne Robert, Bernard Meunier
Published in: Chemistry - A European Journal, Issue 24/31, 2018, Page(s) 7825-7829, ISSN 0947-6539
DOI: 10.1002/chem.201801387

A Metallo Pro-Drug to Target Cu II in the Context of Alzheimer's Disease

Author(s): Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, Christelle Hureau
Published in: Chemistry - A European Journal, Issue 24/20, 2018, Page(s) 5095-5099, ISSN 0947-6539
DOI: 10.1002/chem.201706049

Ascorbate Oxidation by Cu(Amyloid-β) Complexes: Determination of the Intrinsic Rate as a Function of Alterations in the Peptide Sequence Revealing Key Residues for Reactive Oxygen Species Production

Author(s): Elena Atrián-Blasco, Melisa del Barrio, Peter Faller, Christelle Hureau
Published in: Analytical Chemistry, Issue 90/9, 2018, Page(s) 5909-5915, ISSN 0003-2700
DOI: 10.1021/acs.analchem.8b00740

N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications

Author(s): Paulina Gonzalez, Karolina Bossak, Ewelina Stefaniak, Christelle Hureau, Laurent Raibaut, Wojciech Bal, Peter Faller
Published in: Chemistry - A European Journal, Issue 24/32, 2018, Page(s) 8029-8041, ISSN 0947-6539
DOI: 10.1002/chem.201705398

Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance

Author(s): Elena Atrián-Blasco, Paulina Gonzalez, Alice Santoro, Bruno Alies, Peter Faller, Christelle Hureau
Published in: Coordination Chemistry Reviews, Issue 371, 2018, Page(s) 38-55, ISSN 0010-8545
DOI: 10.1016/J.CCR.2018.04.007

How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study

Author(s): Amandine Conte-Daban, Adam Day, Peter Faller, Christelle Hureau
Published in: Dalton Trans., Issue 45/39, 2016, Page(s) 15671-15678, ISSN 1477-9226
DOI: 10.1039/C6DT02308H

Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides

Author(s): Bruno Alies, Amandine Conte-Daban, Stéphanie Sayen, Fabrice Collin, Isabelle Kieffer, Emmanuel Guillon, Peter Faller, Christelle Hureau
Published in: Inorganic Chemistry, Issue 55/20, 2016, Page(s) 10499-10509, ISSN 0020-1669
DOI: 10.1021/acs.inorgchem.6b01733

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

Author(s): Clémence Cheignon, Fabrice Collin, Peter Faller, Christelle Hureau
Published in: Dalton Trans., Issue 45/32, 2016, Page(s) 12627-12631, ISSN 1477-9226
DOI: 10.1039/C6DT01979J

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

Author(s): Clémence Cheignon, Peter Faller, Denis Testemale, Christelle Hureau, Fabrice Collin
Published in: Metallomics, Issue 8/10, 2016, Page(s) 1081-1089, ISSN 1756-5901
DOI: 10.1039/C6MT00150E

Triggering Cu-coordination change in Cu( ii )-Ala-His-His by external ligands

Author(s): Paulina Gonzalez, Karolina Bossak-Ahmad, Bertrand Vileno, Nina E. Wezynfeld, Youssef El Khoury, Petra Hellwig, Christelle Hureau, Wojciech Bal, Peter Faller
Published in: Chemical Communications, Issue 55/56, 2019, Page(s) 8110-8113, ISSN 1359-7345
DOI: 10.1039/c9cc03174j

Role of PTA in the prevention of Cu(amyloid-β) induced ROS formation and amyloid-β oligomerisation in the presence of Zn

Author(s): Elena Atrián-Blasco, Elena Cerrada, Peter Faller, Mariano Laguna, Christelle Hureau
Published in: Metallomics, Issue 11/6, 2019, Page(s) 1154-1161, ISSN 1756-5901
DOI: 10.1039/C9MT00011A

Mutations of Histidine 13 to Arginine and Arginine 5 to Glycine Are Responsible for Different Coordination Sites of Zinc(II) to Human and Murine Peptides

Author(s): Bruno Aliès, Valentina Borghesani, Sabrina Noël, Stephanie Sayen, Emmanuel Guillon, Denis Testemale, Peter Faller, Christelle Hureau
Published in: Chemistry – A European Journal, Issue 24/53, 2018, Page(s) 14233-14241, ISSN 0947-6539
DOI: 10.1002/chem.201802759

Kinetics Are Crucial When Targeting Copper Ions to Fight Alzheimer's Disease: An Illustration with Azamacrocyclic Ligands

Author(s): Amandine Conte-Daban, Maryline Beyler, Raphaël Tripier, Christelle Hureau
Published in: Chemistry - A European Journal, Issue 24/33, 2018, Page(s) 8447-8452, ISSN 0947-6539
DOI: 10.1002/chem.201801520

Copper Binding to Amyloid-β Peptides

Author(s): Arlette Itken-Fuder, Christelle Hureau
Published in: ChemViews, 2017, ISSN 2190-3735
DOI: 10.1002/chemv.201700081

Metal-binding to Amyloid-β Peptide: Coordination, Aggregation and Reactive Oxygen Species Production

Author(s): del Barrio, Melisa; Borghesani, Valentina; Hureau, Christelle; Faller, Peter
Published in: https://www.elsevier.com/books/biometals-in-neurodegenerative-diseases/white/978-0-12-804562-6, Issue 1, 2017

Metal Ions and Complexes in Alzheimer's Disease: From Fundamental to Therapeutic Perspectives

Author(s): Hureau, Christelle
Published in: R. A. Scott. Encyclopedia of Inorganic and Bioinorganic Chemistry, John Wiley & Sons, Ltd, 2018, Issue 1, 2019