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Alzheimer's disease and Zinc: the missing link ?

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Keggin-type polyoxometalates as Cu( ii ) chelators in the context of Alzheimer's disease

Author(s): Elena Atrián-Blasco, Lucie de Cremoux, Xudong Lin, Rufus Mitchell-Heggs, Laurent Sabater, Sébastien Blanchard, Christelle Hureau
Published in: Chemical Communications, 2022, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc05792h

The Aggregation Pattern of Aβ 1–40 is Altered by the Presence of N ‐Truncated Aβ 4–40 and/or Cu II in a Similar Way through Ionic Interactions

Author(s): Ewelina Stefaniak, Elena Atrian‐Blasco, Wojciech Goch, Laurent Sabater, Christelle Hureau, Wojciech Bal
Published in: Chemistry – A European Journal, Issue 27/8, 2021, Page(s) 2798-2809, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004484

Unexpected Trends in Copper Removal from Aβ Peptide: When Less Ligand Is Better and Zn Helps.

Author(s): Charlène Esmieu; Raúl Balderrama-Martínez-Sotomayor; Amandine Conte-Daban; Olga Iranzo; Christelle Hureau
Published in: "Inorganic Chemistry, American Chemical Society, 2021, 60 (2), pp.1248-1256. ⟨10.1021/acs.inorgchem.0c03407⟩", 2021, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.0c03407

Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

Author(s): Elena Atrián-Blasco, Elena Cerrada, Amandine Conte-Daban, Denis Testemale, Peter Faller, Mariano Laguna, Christelle Hureau
Published in: Metallomcs, 2015, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1039/c5mt00077g

Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies

Author(s): Charlène Esmieu, Djamila Guettas, Amandine Conte-Daban, Laurent Sabater, Peter Faller, Christelle Hureau
Published in: Inorganic Chemistry, Issue 58/20, 2019, Page(s) 13509-13527, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b00995

The aroylhydrazone INHHQ prevents memory impairment induced by Alzheimer's-linked amyloid-β oligomers in mice.

Author(s): Anna De Falco; Grasielle C. Kincheski; Elena Atrián-Blasco; Christelle Hureau; Sergio T. Ferreira; Nicolás A. Rey
Published in: https://hal.archives-ouvertes.fr/hal-03412868, Issue 8, 2020, ISSN 0955-8810
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/fbp.0000000000000578

Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal With Them

Author(s): Faller, P.; Hureau, C.
Published in: Frontiers in Chemistry, 2021, ISSN 2296-2646
Publisher: Frontiers Media S.A.
DOI: 10.3389/fchem.2020.611227

(Bio)chemical Strategies To Modulate Amyloid-β Self-Assembly

Author(s): Sara Ayala, Pierre Genevaux, Christelle Hureau, Peter Faller
Published in: ACS Chemical Neuroscience, Issue 10/8, 2019, Page(s) 3366-3374, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.9b00239

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

Author(s): Clémence Cheignon, Megan Jones, Elena Atrián-Blasco, Isabelle Kieffer, Peter Faller, Fabrice Collin, Christelle Hureau
Published in: Chem. Sci., Issue 8/7, 2017, Page(s) 5107-5118, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7SC00809K

Link between Affinity and Cu(II) Binding Sites to Amyloid-β Peptides Evaluated by a New Water-Soluble UV–Visible Ratiometric Dye with a Moderate Cu(II) Affinity

Author(s): Amandine Conte-Daban, Valentina Borghesani, Stéphanie Sayen, Emmanuel Guillon, Yves Journaux, Geoffrey Gontard, Laurent Lisnard, Christelle Hureau
Published in: Analytical Chemistry, Issue 89/3, 2017, Page(s) 2155-2162, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.6b04979

A Trishistidine Pseudopeptide with Ability to Remove Both Cu Ι and Cu ΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation

Author(s): Amandine Conte-Daban, Bastien Boff, Andreza Candido Matias, Claudia N. Montes Aparicio, Christelle Gateau, Colette Lebrun, Giselle Cerchiaro, Isabelle Kieffer, Stéphanie Sayen, Emmanuel Guillon, Pascale Delangle, Christelle Hureau
Published in: Chemistry - A European Journal, 2017, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201703429

Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteins

Author(s): Elena Atrián-Blasco, Alice Santoro, Dean L. Pountney, Gabriele Meloni, Christelle Hureau, Peter Faller
Published in: Chemical Society Reviews, 2017, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7CS00448F

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Author(s): C. Cheignon, M. Tomas, D. Bonnefont-Rousselot, P. Faller, C. Hureau, F. Collin
Published in: Redox Biology, Issue 14, 2018, Page(s) 450-464, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2017.10.014

Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level

Author(s): Elena Atrián-Blasco, Amandine Conte-Daban, Christelle Hureau
Published in: Dalton Trans., Issue 46/38, 2017, Page(s) 12750-12759, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7DT01344B

Cu II Binding to Various Forms of Amyloid-β Peptides: Are They Friends or Foes?

Author(s): Valentina Borghesani, Bruno Alies, Christelle Hureau
Published in: European Journal of Inorganic Chemistry, 2017, ISSN 1434-1948
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201700776

N 4 -Tetradentate Chelators Efficiently Regulate Copper Homeostasis and Prevent ROS Production Induced by Copper-Amyloid-β 1-16

Author(s): Weixin Zhang, Yan Liu, Christelle Hureau, Anne Robert, Bernard Meunier
Published in: Chemistry - A European Journal, Issue 24/31, 2018, Page(s) 7825-7829, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201801387

A Metallo Pro-Drug to Target Cu II in the Context of Alzheimer's Disease

Author(s): Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, Christelle Hureau
Published in: Chemistry - A European Journal, Issue 24/20, 2018, Page(s) 5095-5099, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201706049

Ascorbate Oxidation by Cu(Amyloid-β) Complexes: Determination of the Intrinsic Rate as a Function of Alterations in the Peptide Sequence Revealing Key Residues for Reactive Oxygen Species Production

Author(s): Elena Atrián-Blasco, Melisa del Barrio, Peter Faller, Christelle Hureau
Published in: Analytical Chemistry, Issue 90/9, 2018, Page(s) 5909-5915, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.8b00740

N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications

Author(s): Paulina Gonzalez, Karolina Bossak, Ewelina Stefaniak, Christelle Hureau, Laurent Raibaut, Wojciech Bal, Peter Faller
Published in: Chemistry - A European Journal, Issue 24/32, 2018, Page(s) 8029-8041, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201705398

Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance

Author(s): Elena Atrián-Blasco, Paulina Gonzalez, Alice Santoro, Bruno Alies, Peter Faller, Christelle Hureau
Published in: Coordination Chemistry Reviews, Issue 371, 2018, Page(s) 38-55, ISSN 0010-8545
Publisher: Elsevier BV
DOI: 10.1016/J.CCR.2018.04.007

How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study

Author(s): Amandine Conte-Daban, Adam Day, Peter Faller, Christelle Hureau
Published in: Dalton Trans., Issue 45/39, 2016, Page(s) 15671-15678, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6DT02308H

Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides

Author(s): Bruno Alies, Amandine Conte-Daban, Stéphanie Sayen, Fabrice Collin, Isabelle Kieffer, Emmanuel Guillon, Peter Faller, Christelle Hureau
Published in: Inorganic Chemistry, Issue 55/20, 2016, Page(s) 10499-10509, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.6b01733

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

Author(s): Clémence Cheignon, Fabrice Collin, Peter Faller, Christelle Hureau
Published in: Dalton Trans., Issue 45/32, 2016, Page(s) 12627-12631, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6DT01979J

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

Author(s): Clémence Cheignon, Peter Faller, Denis Testemale, Christelle Hureau, Fabrice Collin
Published in: Metallomics, Issue 8/10, 2016, Page(s) 1081-1089, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6MT00150E

Triggering Cu-coordination change in Cu( ii )-Ala-His-His by external ligands

Author(s): Paulina Gonzalez, Karolina Bossak-Ahmad, Bertrand Vileno, Nina E. Wezynfeld, Youssef El Khoury, Petra Hellwig, Christelle Hureau, Wojciech Bal, Peter Faller
Published in: Chemical Communications, Issue 55/56, 2019, Page(s) 8110-8113, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc03174j

Role of PTA in the prevention of Cu(amyloid-β) induced ROS formation and amyloid-β oligomerisation in the presence of Zn

Author(s): Elena Atrián-Blasco, Elena Cerrada, Peter Faller, Mariano Laguna, Christelle Hureau
Published in: Metallomics, Issue 11/6, 2019, Page(s) 1154-1161, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1039/C9MT00011A

Mutations of Histidine 13 to Arginine and Arginine 5 to Glycine Are Responsible for Different Coordination Sites of Zinc(II) to Human and Murine Peptides

Author(s): Bruno Aliès, Valentina Borghesani, Sabrina Noël, Stephanie Sayen, Emmanuel Guillon, Denis Testemale, Peter Faller, Christelle Hureau
Published in: Chemistry – A European Journal, Issue 24/53, 2018, Page(s) 14233-14241, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802759

Kinetics Are Crucial When Targeting Copper Ions to Fight Alzheimer's Disease: An Illustration with Azamacrocyclic Ligands

Author(s): Amandine Conte-Daban, Maryline Beyler, Raphaël Tripier, Christelle Hureau
Published in: Chemistry - A European Journal, Issue 24/33, 2018, Page(s) 8447-8452, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201801520

Concentration‐Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin**

Author(s): Saida Majdoub, Zoltán Garda, Alexandre C. Oliveira, Inga Relich, Agnès Pallier, Sara Lacerda, Christelle Hureau, Carlos F. G. C. Geraldes, Jean‐François Morfin, Éva Tóth
Published in: Chemistry – A European Journal, Issue 27/6, 2021, Page(s) 2009-2020, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004000

Hybrid Bis-Histidine Phenanthroline-Based Ligands to Lessen Aβ-Bound Cu ROS Production: An Illustration of Cu(I) Significance

Author(s): Marielle Drommi, Clément Rulmont, Charlène Esmieu, Christelle Hureau
Published in: Molecules, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26247630

Impact of N-Truncated Aβ Peptides on Cu- and Cu(Aβ)-Generated ROS: CuI Matters!

Author(s): Charlène Esmieu, Guillaume Ferrand, Valentina Borghesani, Christelle Hureau
Published in: Chemistry a european journal, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003949

A Water‐Soluble Peptoid Chelator that Can Remove Cu 2+ from Amyloid‐β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease

Author(s): Anastasia E. Behar, Laurent Sabater, Maria Baskin, Christelle Hureau, Galia Maayan
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202109758

Measurement of Interpeptidic Cu II Exchange Rate Constants of Cu II -Amyloid-β Complexes to Small Peptide Motifs by Tryptophan Fluorescence Quenching

Author(s): Cheryle N. Beuning, Luca J. Zocchi, Kyangwi P. Malikidogo, Charlène Esmieu, Pierre Dorlet, Debbie C. Crans, Christelle Hureau
Published in: Inorganic Chemistry, Issue 60/11, 2021, Page(s) 7650-7659, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.0c03555

Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production

Author(s): Melisa del Barrio, Valentina Borghesani, Christelle Hureau, Peter Faller
Published in: Biometals in Neurodegenerative Diseases, 2017, Page(s) 265-281, ISBN 9780128045626
Publisher: Elsevier
DOI: 10.1016/b978-0-12-804562-6.00014-2

Role of Metal Ions in Alzheimer’s Disease: Mechanistic Aspects Contributing to Neurotoxicity

Author(s): Christelle HUREAU
Published in: Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities, 2022
Publisher: Royal Society of Chemistry

Metal ions and complexes in Alzheimer diseases: from fundamental to therapeutic perspectives.

Author(s): Christelle HUREAU
Published in: Encyclopedia of Inorganic and Bioinorganic Chemistry, 2019
Publisher: John Wiley and Sons

Copper Binding to Amyloid-β Peptides

Author(s): Arlette Itken-Fuder, Christelle Hureau
Published in: ChemViews, 2017, ISSN 2190-3735
Publisher: Wiley-VCH and ChemPubSoc Europe
DOI: 10.1002/chemv.201700081

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