Alzheimer's disease and Zinc: the missing link ?

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Pubblicazioni

Keggin-type polyoxometalates as Cu( ii ) chelators in the context of Alzheimer's disease

Autori: Elena Atrián-Blasco, Lucie de Cremoux, Xudong Lin, Rufus Mitchell-Heggs, Laurent Sabater, Sébastien Blanchard, Christelle Hureau
Pubblicato in: Chemical Communications, 2022, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cc05792h

The Aggregation Pattern of Aβ 1–40 is Altered by the Presence of N ‐Truncated Aβ 4–40 and/or Cu II in a Similar Way through Ionic Interactions

Autori: Ewelina Stefaniak, Elena Atrian‐Blasco, Wojciech Goch, Laurent Sabater, Christelle Hureau, Wojciech Bal
Pubblicato in: Chemistry – A European Journal, Numero 27/8, 2021, Pagina/e 2798-2809, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004484

Unexpected Trends in Copper Removal from Aβ Peptide: When Less Ligand Is Better and Zn Helps.

Autori: Charlène Esmieu; Raúl Balderrama-Martínez-Sotomayor; Amandine Conte-Daban; Olga Iranzo; Christelle Hureau
Pubblicato in: "Inorganic Chemistry, American Chemical Society, 2021, 60 (2), pp.1248-1256. ⟨10.1021/acs.inorgchem.0c03407⟩", 2021, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.0c03407

Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

Autori: Elena Atrián-Blasco, Elena Cerrada, Amandine Conte-Daban, Denis Testemale, Peter Faller, Mariano Laguna, Christelle Hureau
Pubblicato in: Metallomcs, 2015, ISSN 1756-5901
Editore: Royal Society of Chemistry
DOI: 10.1039/c5mt00077g

Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies

Autori: Charlène Esmieu, Djamila Guettas, Amandine Conte-Daban, Laurent Sabater, Peter Faller, Christelle Hureau
Pubblicato in: Inorganic Chemistry, Numero 58/20, 2019, Pagina/e 13509-13527, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b00995

The aroylhydrazone INHHQ prevents memory impairment induced by Alzheimer's-linked amyloid-β oligomers in mice.

Autori: Anna De Falco; Grasielle C. Kincheski; Elena Atrián-Blasco; Christelle Hureau; Sergio T. Ferreira; Nicolás A. Rey
Pubblicato in: https://hal.archives-ouvertes.fr/hal-03412868, Numero 8, 2020, ISSN 0955-8810
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/fbp.0000000000000578

Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal With Them

Autori: Faller, P.; Hureau, C.
Pubblicato in: Frontiers in Chemistry, 2021, ISSN 2296-2646
Editore: Frontiers Media S.A.
DOI: 10.3389/fchem.2020.611227

(Bio)chemical Strategies To Modulate Amyloid-β Self-Assembly

Autori: Sara Ayala, Pierre Genevaux, Christelle Hureau, Peter Faller
Pubblicato in: ACS Chemical Neuroscience, Numero 10/8, 2019, Pagina/e 3366-3374, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.9b00239

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

Autori: Clémence Cheignon, Megan Jones, Elena Atrián-Blasco, Isabelle Kieffer, Peter Faller, Fabrice Collin, Christelle Hureau
Pubblicato in: Chem. Sci., Numero 8/7, 2017, Pagina/e 5107-5118, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/C7SC00809K

Link between Affinity and Cu(II) Binding Sites to Amyloid-β Peptides Evaluated by a New Water-Soluble UV–Visible Ratiometric Dye with a Moderate Cu(II) Affinity

Autori: Amandine Conte-Daban, Valentina Borghesani, Stéphanie Sayen, Emmanuel Guillon, Yves Journaux, Geoffrey Gontard, Laurent Lisnard, Christelle Hureau
Pubblicato in: Analytical Chemistry, Numero 89/3, 2017, Pagina/e 2155-2162, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.6b04979

A Trishistidine Pseudopeptide with Ability to Remove Both Cu Ι and Cu ΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation

Autori: Amandine Conte-Daban, Bastien Boff, Andreza Candido Matias, Claudia N. Montes Aparicio, Christelle Gateau, Colette Lebrun, Giselle Cerchiaro, Isabelle Kieffer, Stéphanie Sayen, Emmanuel Guillon, Pascale Delangle, Christelle Hureau
Pubblicato in: Chemistry - A European Journal, 2017, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201703429

Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteins

Autori: Elena Atrián-Blasco, Alice Santoro, Dean L. Pountney, Gabriele Meloni, Christelle Hureau, Peter Faller
Pubblicato in: Chemical Society Reviews, 2017, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/C7CS00448F

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Autori: C. Cheignon, M. Tomas, D. Bonnefont-Rousselot, P. Faller, C. Hureau, F. Collin
Pubblicato in: Redox Biology, Numero 14, 2018, Pagina/e 450-464, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2017.10.014

Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level

Autori: Elena Atrián-Blasco, Amandine Conte-Daban, Christelle Hureau
Pubblicato in: Dalton Trans., Numero 46/38, 2017, Pagina/e 12750-12759, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/C7DT01344B

Cu II Binding to Various Forms of Amyloid-β Peptides: Are They Friends or Foes?

Autori: Valentina Borghesani, Bruno Alies, Christelle Hureau
Pubblicato in: European Journal of Inorganic Chemistry, 2017, ISSN 1434-1948
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201700776

N 4 -Tetradentate Chelators Efficiently Regulate Copper Homeostasis and Prevent ROS Production Induced by Copper-Amyloid-β 1-16

Autori: Weixin Zhang, Yan Liu, Christelle Hureau, Anne Robert, Bernard Meunier
Pubblicato in: Chemistry - A European Journal, Numero 24/31, 2018, Pagina/e 7825-7829, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201801387

A Metallo Pro-Drug to Target Cu II in the Context of Alzheimer's Disease

Autori: Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, Christelle Hureau
Pubblicato in: Chemistry - A European Journal, Numero 24/20, 2018, Pagina/e 5095-5099, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201706049

Ascorbate Oxidation by Cu(Amyloid-β) Complexes: Determination of the Intrinsic Rate as a Function of Alterations in the Peptide Sequence Revealing Key Residues for Reactive Oxygen Species Production

Autori: Elena Atrián-Blasco, Melisa del Barrio, Peter Faller, Christelle Hureau
Pubblicato in: Analytical Chemistry, Numero 90/9, 2018, Pagina/e 5909-5915, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.8b00740

N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications

Autori: Paulina Gonzalez, Karolina Bossak, Ewelina Stefaniak, Christelle Hureau, Laurent Raibaut, Wojciech Bal, Peter Faller
Pubblicato in: Chemistry - A European Journal, Numero 24/32, 2018, Pagina/e 8029-8041, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201705398

Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance

Autori: Elena Atrián-Blasco, Paulina Gonzalez, Alice Santoro, Bruno Alies, Peter Faller, Christelle Hureau
Pubblicato in: Coordination Chemistry Reviews, Numero 371, 2018, Pagina/e 38-55, ISSN 0010-8545
Editore: Elsevier BV
DOI: 10.1016/J.CCR.2018.04.007

How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study

Autori: Amandine Conte-Daban, Adam Day, Peter Faller, Christelle Hureau
Pubblicato in: Dalton Trans., Numero 45/39, 2016, Pagina/e 15671-15678, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/C6DT02308H

Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides

Autori: Bruno Alies, Amandine Conte-Daban, Stéphanie Sayen, Fabrice Collin, Isabelle Kieffer, Emmanuel Guillon, Peter Faller, Christelle Hureau
Pubblicato in: Inorganic Chemistry, Numero 55/20, 2016, Pagina/e 10499-10509, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.6b01733

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

Autori: Clémence Cheignon, Fabrice Collin, Peter Faller, Christelle Hureau
Pubblicato in: Dalton Trans., Numero 45/32, 2016, Pagina/e 12627-12631, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/C6DT01979J

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

Autori: Clémence Cheignon, Peter Faller, Denis Testemale, Christelle Hureau, Fabrice Collin
Pubblicato in: Metallomics, Numero 8/10, 2016, Pagina/e 1081-1089, ISSN 1756-5901
Editore: Royal Society of Chemistry
DOI: 10.1039/C6MT00150E

Triggering Cu-coordination change in Cu( ii )-Ala-His-His by external ligands

Autori: Paulina Gonzalez, Karolina Bossak-Ahmad, Bertrand Vileno, Nina E. Wezynfeld, Youssef El Khoury, Petra Hellwig, Christelle Hureau, Wojciech Bal, Peter Faller
Pubblicato in: Chemical Communications, Numero 55/56, 2019, Pagina/e 8110-8113, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc03174j

Role of PTA in the prevention of Cu(amyloid-β) induced ROS formation and amyloid-β oligomerisation in the presence of Zn

Autori: Elena Atrián-Blasco, Elena Cerrada, Peter Faller, Mariano Laguna, Christelle Hureau
Pubblicato in: Metallomics, Numero 11/6, 2019, Pagina/e 1154-1161, ISSN 1756-5901
Editore: Royal Society of Chemistry
DOI: 10.1039/C9MT00011A

Mutations of Histidine 13 to Arginine and Arginine 5 to Glycine Are Responsible for Different Coordination Sites of Zinc(II) to Human and Murine Peptides

Autori: Bruno Aliès, Valentina Borghesani, Sabrina Noël, Stephanie Sayen, Emmanuel Guillon, Denis Testemale, Peter Faller, Christelle Hureau
Pubblicato in: Chemistry – A European Journal, Numero 24/53, 2018, Pagina/e 14233-14241, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201802759

Kinetics Are Crucial When Targeting Copper Ions to Fight Alzheimer's Disease: An Illustration with Azamacrocyclic Ligands

Autori: Amandine Conte-Daban, Maryline Beyler, Raphaël Tripier, Christelle Hureau
Pubblicato in: Chemistry - A European Journal, Numero 24/33, 2018, Pagina/e 8447-8452, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201801520

Concentration‐Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin**

Autori: Saida Majdoub, Zoltán Garda, Alexandre C. Oliveira, Inga Relich, Agnès Pallier, Sara Lacerda, Christelle Hureau, Carlos F. G. C. Geraldes, Jean‐François Morfin, Éva Tóth
Pubblicato in: Chemistry – A European Journal, Numero 27/6, 2021, Pagina/e 2009-2020, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004000

Hybrid Bis-Histidine Phenanthroline-Based Ligands to Lessen Aβ-Bound Cu ROS Production: An Illustration of Cu(I) Significance

Autori: Marielle Drommi, Clément Rulmont, Charlène Esmieu, Christelle Hureau
Pubblicato in: Molecules, 2022, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26247630

Impact of N-Truncated Aβ Peptides on Cu- and Cu(Aβ)-Generated ROS: CuI Matters!

Autori: Charlène Esmieu, Guillaume Ferrand, Valentina Borghesani, Christelle Hureau
Pubblicato in: Chemistry a european journal, 2021, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003949

A Water‐Soluble Peptoid Chelator that Can Remove Cu 2+ from Amyloid‐β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease

Autori: Anastasia E. Behar, Laurent Sabater, Maria Baskin, Christelle Hureau, Galia Maayan
Pubblicato in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202109758

Measurement of Interpeptidic Cu II Exchange Rate Constants of Cu II -Amyloid-β Complexes to Small Peptide Motifs by Tryptophan Fluorescence Quenching

Autori: Cheryle N. Beuning, Luca J. Zocchi, Kyangwi P. Malikidogo, Charlène Esmieu, Pierre Dorlet, Debbie C. Crans, Christelle Hureau
Pubblicato in: Inorganic Chemistry, Numero 60/11, 2021, Pagina/e 7650-7659, ISSN 0020-1669
Editore: American Chemical Society
DOI: 10.1021/acs.inorgchem.0c03555

Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production

Autori: Melisa del Barrio, Valentina Borghesani, Christelle Hureau, Peter Faller
Pubblicato in: Biometals in Neurodegenerative Diseases, 2017, Pagina/e 265-281, ISBN 9780128045626
Editore: Elsevier
DOI: 10.1016/b978-0-12-804562-6.00014-2

Role of Metal Ions in Alzheimer’s Disease: Mechanistic Aspects Contributing to Neurotoxicity

Autori: Christelle HUREAU
Pubblicato in: Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities, 2022
Editore: Royal Society of Chemistry

Metal ions and complexes in Alzheimer diseases: from fundamental to therapeutic perspectives.

Autori: Christelle HUREAU
Pubblicato in: Encyclopedia of Inorganic and Bioinorganic Chemistry, 2019
Editore: John Wiley and Sons

Copper Binding to Amyloid-β Peptides

Autori: Arlette Itken-Fuder, Christelle Hureau
Pubblicato in: ChemViews, 2017, ISSN 2190-3735
Editore: Wiley-VCH and ChemPubSoc Europe
DOI: 10.1002/chemv.201700081

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