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Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets

Objective

Antimicrobial resistance is posing a continuously-rising threat to global health. Indeed, one key recommendation from the recent “Action plan against the rising threats from Antimicrobial Resistance” report (submitted by the Commission to the European Parliament and Council (15.11.2011)) is the development of effective antimicrobials or alternatives for treatment of human and animal infections. The INTEGRATE project is a direct response to this. We have assembled a team of 10 beneficiaries from eight EU member states, encompassing both academic and non-academic sectors and different disciplines, to form a consortium committed to training Early Stage Researchers (ESRs) in the discovery and preclinical validation of novel Gram-negative antibacterial agents and antibacterial targets. The principle aim of the consortium is to provide a training platform where students are exposed to every aspect of the antimicrobial discovery process, ranging from target identification and validation, through organic synthesis, in silico design and compound screening, to mode-of-action and possible resistance mechanisms. This exposure will be accomplished through a concrete secondment plan, coupled with a series of high-level consortium-wide training events and networking programmes. Our intention is to reverse the current fragmentation of approaches towards antibacterial discovery through mutual cooperation. The INTEGRATE training framework is built on an innovative research project aimed at targeting important but non-essential gene products as an effective means of reducing bacterial fitness, thereby facilitating clearance of the pathogen by the host immune system. To achieve this, the individual work programmes have been designed to seamlessly inter-mesh contributions from the fields of in silico design, organic synthesis, molecular biology and biochemistry, and the very latest in vitro and in vivo screening technologies.
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Coordinator

UNIVERSITA DEGLI STUDI DI PARMA

Address

Via Universita 12
43100 Parma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 516 122,64

Participants (9)

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HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 269 145,36

ITA-SUOMEN YLIOPISTO

Finland

EU Contribution

€ 269 145,36

LATVIJAS ORGANISKAS SINTEZES INSTITUTS

Latvia

EU Contribution

€ 223 577,64

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 273 287,88

UNIVERZA V LJUBLJANI

Slovenia

EU Contribution

€ 234 997,56

TAROS CHEMICALS GMBH & CO KG

Germany

EU Contribution

€ 249 216,48

UNIVERSITEIT ANTWERPEN

Belgium

EU Contribution

€ 250 560

APTUIT (VERONA) SRL

Italy

EU Contribution

€ 258 061,32

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 249 216,48

Partners (4)

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CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY

Matera, Lda

Finnish Patent Office and Registration

TTY-SAATIO

Project information

Grant agreement ID: 642620

Status

Closed project

  • Start date

    1 January 2015

  • End date

    31 December 2018

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 793 330,72

  • EU contribution

    € 2 793 330,72

Coordinated by:

UNIVERSITA DEGLI STUDI DI PARMA

Italy